LAMP1 anticorps

N° du produit ABIN497981

L’anticorps Lapin Polyclonal anti-LAMP1 a été validé pour WB, IF et EIA. Il convient pour détecter LAMP1 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour LAMP1 anticorps (ABIN497981)

Antigène: LAMP1 (Lysosomal-Associated Membrane Protein 1 (LAMP1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LAMP1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Détail du produit anti-LAMP1 anticorps

Specificité: Recognizes CD107a/LAMP1 (Center).

Réactivité croisée (Details): Species reactivity (tested):Human, Mouse, Rat

Purification: Immunoaffinity Chromatography

Immunogène: LAMP1 antibody was raised against a 15 amino acid peptide from near the center of Human LAMP-1.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: CD107a/LAMP1 antibody can be used for the detection of CD107a/LAMP1 at1-2 μg/mL. Despite its predicted size, LAMP-1 migrates at 110 kDa in SDS-PAGE. Positive Control: EL4 Cell Lysate. Immunofluorescence. Positive Control: Human Colon Tissue Lysate.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C. Antibodies should not be exposed to prolonged high temperatures.

Détails sur LAMP1

Antigène: LAMP1 (Lysosomal-Associated Membrane Protein 1 (LAMP1))

Autre désignation: CD107a / LAMP1

Sujet: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components (1,2) and is negatively regulated by TOR (Target of rapamycin) (3). A protein recently found to be involved in autophagy, LAMP-2, is a highly glycosylated protein associated with the lysosome (4,5). LAMP-1 shares much homology to LAMP-2 and is thought to have overlapping functions. Mice lacking LAMP-1 had very minor defects compared to those deficient in LAMP-2 expression (6). However, the loss of both proteins resulted in embryonic lethality (7), suggesting that each protein possesses some unique and necessary functions.Synonyms: CD107 Antigen-like Family Member A, LAMP-1, LAMPA, LGP120, Lysosome-associated membrane glycoprotein 1

ID gène: 3916

NCBI Accession: NP_005552

UniProt: P11279

Pathways: Autophagy