BCAR1 anticorps

N° du produit ABIN498158

L’anticorps anti-BCAR1 Polyclonal Lapin est utilisé pour la détection de BCAR1 dans des échantillons de Humain, Souris et Rat. Il a été validé pour IHC (p).

Aperçu rapide pour BCAR1 anticorps (ABIN498158)

Antigène: BCAR1 (Breast Cancer Anti-Estrogen Resistance 1 (BCAR1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BCAR1 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-BCAR1 anticorps

Specificité: This antibody detects endogenous levels of p130 Cas protein.

Réactivité croisée (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity chromatography using epitope-specific immunogen

Pureté: > 95 % (by SDS-PAGE)

Information d'application

Indications d'application: Immunohistochemistry on paraffin sections: 1: 50 - 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur BCAR1

Antigène: BCAR1 (Breast Cancer Anti-Estrogen Resistance 1 (BCAR1))

Autre désignation: BCAR1 / CRKAS

Sujet: Two retinoblastoma related proteins, p107 and pRb2 / p130, which are structurally and functionally similar to the product of the retinoblastoma gene (pRb / p105), were cloned by taking advantage of their ability to bind transforming proteins of DNA tumor viruses through a particular region called the pocket domain. Like pRb, both proteins play a fundamental role in growth control. These Rb family proteins were measured in a variety of lung neoplasms. The highest percentage of undetectable levels and the tightest inverse correlation with the histological grading and with PCNA expression in the most aggressive tumor types were found for pRb2 / p130, which may suggest an important role for this protein in the pathogenesis and progression of lung cancer.Synonyms: Breast cancer anti-estrogen resistance protein 1, CASS1, CRK-associated substrate, Cas scaffolding protein family member 1, p130cas, p130cas

Poids moléculaire: approx. 130 kDa

ID gène: 9564

NCBI Accession: NP_055382

UniProt: P56945

Pathways: EGFR Signaling Pathway, Neurotrophin Signaling Pathway, CXCR4-mediated Signaling Events, Platelet-derived growth Factor Receptor Signaling