ESPL1
Reactivité: Humain, Souris
ELISA, IHC, WB, IF
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
Western blot: 1: 500 - 1: 1000. Immunohistochemistry on paraffin sections: 1: 50 - 1: 200. Immunoflourescence: 1: 50 - 1: 200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
anticorps ESP1, anticorps SEPA, anticorps mp:zf637-3-001691, anticorps AL024103, anticorps AU045071, anticorps Cerp, anticorps PRCE, anticorps SSE, anticorps extra spindle pole bodies like 1, separase, anticorps extra spindle poles like 1, anticorps extra spindle pole bodies 1, separase, anticorps ESPL1, anticorps espl1, anticorps Espl1
Sujet
Separase is a cysteine protease that triggers anaphase in all eukaryotes by participating in separation of sister chromatids during mitosis. Once activated, separase hydrolyzes the SCC1 subunit of cohesin, the chromosomal protein complex responsible for sister chromatid cohesion. Separase and cohesin are highly conserved from yeasts to humans. When the cell is not dividing, separase is prevented from cleaving cohesin through its association with another protein, securin. When anaphase is signaled, the securin is ubiquitinated and hydrolyzed by APC/cyclosome, releasing the active separase. Separase is transiently activated between the two meioses and may also be involved in homolog separation.Synonyms: Caspase-like protein ESPL1, ESP1, Extra spindle poles-like 1 protein, KIAA0165, Separase