Separase anticorps (AA 1220-1500)

N° du produit ABIN7267070

Détail du produit anti-Separase anticorps

Antigène: Separase (ESPL1) (Extra Spindle Poles Like 1 (ESPL1))

Épitope: AA 1220-1500

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Separase est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Fonction: ESPL1 Rabbit pAb

Séquence: DEILAQAYTL LALEGLNQPS NESLQKVLQS GLKFVAARIP HLEPWRASLL LIWALTKLGG LSCCTTQLFA SSWGWQPPLI KSVPGSEPSK TQGQKRSGRG RQKLASAPLR LNNTSQKGLE GRGLPCTPKP PDRIRQAGPH VPFTVFEEVC PTESKPEVPQ APRVQQRVQT RLKVNFSDDS DLEDPVSAEA WLAEEPKRRG TASRGRGRAR KGLSLKTDAV VAPGSAPGNP GLNGRSRRAK KVASRHCEER RPQRASDQAR PGPEIMRTIP EEELTDNWRK M

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 1220-1500 of human ESPL1 (NP_036423.4).

Isotype: IgG

Information d'application

Indications d'application: WB,1:200 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur Separase

Antigène: Separase (ESPL1) (Extra Spindle Poles Like 1 (ESPL1))

Autre désignation: ESPL1 (ESPL1 Produits)

Synonymes: anticorps ESP1, anticorps SEPA, anticorps mp:zf637-3-001691, anticorps AL024103, anticorps AU045071, anticorps Cerp, anticorps PRCE, anticorps SSE, anticorps extra spindle pole bodies like 1, separase, anticorps extra spindle poles like 1, anticorps extra spindle pole bodies 1, separase, anticorps ESPL1, anticorps espl1, anticorps Espl1

Sujet: Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21, MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).[supplied by OMIM, Nov 2010],ESPL1,ESP1,SEPA,separin,Epigenetics & Nuclear Signaling,Cell Biology & Developmental Biology,Apoptosis,Cell Cycle,ESPL1

Poids moléculaire: 197kDa/233kDa

ID gène: 9700

UniProt: Q14674