Clusterin anticorps
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- Antigène Voir toutes Clusterin (CLU) Anticorps
- Clusterin (CLU)
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Reactivité
- Humain, Rat, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp Clusterin est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
- Specificité
- This antibody detects endogenous levels of Clusterin-alpha protein. (region surrounding Glu436)
- Réactivité croisée (Details)
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. - Purification
- Affinity chromatography
- Pureté
- > 95 % by SDS-PAGE
- Top Product
- Discover our top product CLU Anticorps primaire
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- Indications d'application
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Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200. Immuofluorescence: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 1,0 mg/mL
- Buffer
- Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Antigène
- Clusterin (CLU)
- Autre désignation
- Apolipoprotein J (Apo J) (CLU Produits)
- Synonymes
- anticorps LOC100136120, anticorps clu, anticorps MGC53055, anticorps zgc:73352, anticorps xclu, anticorps MGC89163, anticorps CLU, anticorps APO-J, anticorps APOJ, anticorps CLI, anticorps CLU1, anticorps CLU2, anticorps KUB1, anticorps NA1/NA2, anticorps SGP-2, anticorps SGP2, anticorps SP-40, anticorps TRPM-2, anticorps TRPM2, anticorps DAG, anticorps RATTRPM2B, anticorps SP40, anticorps TRPM2B, anticorps Trpm2, anticorps Trpmb, anticorps AI893575, anticorps ApoJ, anticorps Cli, anticorps D14Ucla3, anticorps Sgp-2, anticorps Sgp2, anticorps Sugp-2, anticorps GP80, anticorps gpIII, anticorps 40, anticorps clusterin-1, anticorps clusterin L homeolog, anticorps clusterin, anticorps Clusterin, anticorps LOC100136120, anticorps clu.L, anticorps clu, anticorps CLU, anticorps clus, anticorps Clu, anticorps LOC101113728
- Sujet
- Clusterin, also designated complement lysis inhibitor (CLI), apolipoprotein J (APOJ), sulfated glycoprotein 2 (SGP2), SP-40 and testosterone-repressed prostate message 2 (TRPM2), is a secretory, heterodimeric glycoprotein that influences immune regulation, cell adhesion, transformation, lipid transportation, tissue remodeling, membrane recycling and cell-cell interactions. Clusterin is synthesized as a 449 amino acid poly-peptide that is posttranslationally cleaved at an internal bond between Arg 227 and Ser 228. Two subunits, alpha and beta, are associated through disulfide bonds. The beta subunit (also called ApoJalpha) corresponds to residues 23-227. The alpha subunit (also called ApoJbeta) corresponds to residues 228-449. Overexpression of Clusterin appears to be more common in late stages of mammary tumor progression. Clusterin markedly influences beta-Amyloid structure and neuritic toxicity in vivo and may influence Alzheimer's disease pathogenesis.Synonyms: 40, 40, AAG4, APOJ, Aging-associated gene 4 protein, CLI, Clusterin, Complement cytolysis inhibitor, Complement-associated protein SP-40, KUB1, Ku70-binding protein 1, NA1/NA2, SP-40, Testosterone-repressed prostate message 2
- Poids moléculaire
- approx. 52,70 kDa
- ID gène
- 1191
- NCBI Accession
- NP_001822
- UniProt
- P10909
- Pathways
- Apoptose, Negative Regulation of intrinsic apoptotic Signaling
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