Cyclin D1 anticorps

N° du produit ABIN498398

Il existe 8+ publications pour ce produit. L’anticorps anti-Cyclin D1 Polyclonal Lapin est utilisé pour la détection de Cyclin D1 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB.

Aperçu rapide pour Cyclin D1 anticorps (ABIN498398)

Antigène: Cyclin D1 (CCND1)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Cyclin D1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Cyclin D1 anticorps

Specificité: This antibody detects endogenous levels of Cyclin D1 protein (region surrounding Asp86)

Réactivité croisée (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity chromatography

Pureté: > 95 % by SDS-PAGE

Information d'application

Indications d'application: Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Références pour anticorps anti-Cyclin D1 (ABIN498398)

Goyari, Devi, Bengyella, Khan, Sharma, Kalita, Talukdar: "Unveiling the optimal parameters for cellulolytic characteristics of Talaromyces verruculosus SGMNPf3 and its secretory enzymes." dans: Journal of applied microbiology, Vol. 119, Issue 1, pp. 88-98, (2016) (PubMed).

Smith, Bhattacharya, Williams, Dixon, Powell, Erkina, Erkine: "High-throughput screening system for inhibitors of human Heat Shock Factor 2." dans: Cell stress & chaperones, Vol. 20, Issue 5, pp. 833-41, (2016) (PubMed).

Kushima, Sekine, Matsubara, Taniguchi, Ikegami, Tsuda: "Gastric adenocarcinoma of the fundic gland type shares common genetic and phenotypic features with pyloric gland adenoma." dans: Pathology international, Vol. 63, Issue 6, pp. 318-25, (2015) (PubMed).

Brackeva, De Punt, Kramer, Costa, Verhaeghen, Stangé, Sadones, Xavier, Aerts, Gorus, Martens: "Potential of UCHL1 as biomarker for destruction of pancreatic beta cells." dans: Journal of proteomics, Vol. 117, pp. 156-67, (2015) (PubMed).

Huang, Huang, Li, He, Chen, Yu, Chen, Zhang, Shi, Shan: "Correlation between tuberous sclerosis complex 2 and glycogen synthase kinase 3 beta levels, and outcomes of patients with hepatocellular carcinoma treated by hepatectomy." dans: Hepatology research : the official journal of the Japan Society of Hepatology, Vol. 44, Issue 11, pp. 1142-50, (2014) (PubMed).

Zhang, Fong, Yu, Chen, Wei, Koon, Lau, Leung, Lau, Fung, Yang et al.: "Herbal formula Astragali Radix and Rehmanniae Radix exerted wound healing effect on human skin fibroblast cell line Hs27 via the activation of transformation growth factor (TGF-β) pathway and ..." dans: Phytomedicine : international journal of phytotherapy and phytopharmacology, Vol. 20, Issue 1, pp. 9-16, (2013) (PubMed).

Liu, Liu, Lin, Liu, Hou, Hao, Liu, Zhang, Iwamori: "Lewis y regulate cell cycle related factors in ovarian carcinoma cell RMG-I in vitro via ERK and Akt signaling pathways." dans: International journal of molecular sciences, Vol. 13, Issue 1, pp. 828-39, (2012) (PubMed).

Miura, Kirino, Endo, Morisaka, Kuroda, Takagi, Ueda: "Tracing putative trafficking of the glycolytic enzyme enolase via SNARE-driven unconventional secretion." dans: Eukaryotic cell, Vol. 11, Issue 8, pp. 1075-82, (2012) (PubMed).

Détails sur Cyclin D1

Antigène: Cyclin D1 (CCND1)

Autre désignation: Cyclin D1

Sujet: Considerable effort directed towards the identification of G1 cyclins has led to the isolation of cyclin D, cyclin C and cyclin E. Of these, cyclin D corresponds to a putative human oncogene, designated PRAD1, which maps at the site of the Bcl1 rearrangement in certain lymphomas and leukemias. Two additional human type D cyclins, as well as their mouse homologs, have been identified. Evidence has established that members of the cyclin D family function to regulate phosphorylation of the retinoblastoma gene product, thereby activating E2F transcription factors.Synonyms: BCL-1 oncogene, BCL1, CCND1, Cyclin-D1, G1/S-specific cyclin-D1, PRAD-1 oncogene, PRAD1

Poids moléculaire: approx. 36 kDa

ID gène: 595

NCBI Accession: NP_444284

UniProt: P24385

Pathways: Signalisation PI3K-Akt, Cycle Cellulaire, Mitotic G1-G1/S Phases, ER-Nucleus Signaling