ABL1 anticorps
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- Antigène Voir toutes ABL1 Anticorps
- ABL1 (C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1))
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp ABL1 est non-conjugé
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Application
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Specificité
- This antibody detects endogenous levels of c-Abl protein. (region surrounding Glu883)
- Réactivité croisée (Details)
- Species reactivity (tested):Human, Mouse, Rat.
- Purification
- Affinity chromatography
- Pureté
- > 95 % by SDS-PAGE
- Top Product
- Discover our top product ABL1 Anticorps primaire
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- Indications d'application
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Western Blot: 1/500 -1/1000. Immunohistochemistry: 1/50 - 1/200. Immunofluorescence: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 1,0 mg/mL
- Buffer
- PBS, pH ~7.2, 0.05 % Sodium Azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Antigène
- ABL1 (C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1))
- Autre désignation
- ABL1 (ABL1 Produits)
- Synonymes
- anticorps ABL, anticorps JTK7, anticorps bcr/abl, anticorps c-ABL, anticorps p150, anticorps v-abl, anticorps AI325092, anticorps Abl, anticorps E430008G22Rik, anticorps c-Abl, anticorps ABL proto-oncogene 1, non-receptor tyrosine kinase, anticorps c-abl oncogene 1, non-receptor tyrosine kinase, anticorps Tyrosine-protein kinase abl-1, anticorps ABL1, anticorps Abl1, anticorps abl-1, anticorps abl1
- Sujet
- The Abl oncogene was initially identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV). The major translational product of c-Abl has been identified as a protein with tyrosine kinase activity and an SH2 domain. The Abl oncogene is implicated in several human leukemias including 90-95 % of chronic myelocytic leukemia (CML), 20-25 % of adult acute lymphoblastic leukemia (ALL) and 2-5 % of pediatric ALL. In these leukemias the c-Abl proto-oncogene undergoes a (9,22) chromosomal translocation producing the Philadelphia (Ph1) chromosome. The molecular consequence of this translocation is the generation of a chimeric Bcr/c-Abl mRNA encoding activated Abl protein-tyrosine kinase. The Bcr gene has been shown to encode a GTPase-activating protein (GAP) specific for the Ras-related GTP-binding protein, p21rac.Synonyms: Abelson murine leukemia viral oncogene homolog 1, JTK7, Proto-oncogene tyrosine-protein kinase ABL1, bcr/abl, c-ABL, p150
- Poids moléculaire
- approx. 123 kDa
- ID gène
- 25
- NCBI Accession
- NP_005148
- UniProt
- P00519
- Pathways
- Apoptose, Regulation of Muscle Cell Differentiation, Platelet-derived growth Factor Receptor Signaling, Lipid Metabolism
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