KIT anticorps (pTyr721)

N° du produit ABIN498697

Cet anticorps Lapin Polyclonal détecte spécifiquement KIT dans WB. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour KIT anticorps (pTyr721) (ABIN498697)

Antigène: KIT (Mast/stem Cell Growth Factor Receptor (KIT))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KIT est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-KIT anticorps

Épitope: pTyr721

Specificité: This antibody detects endogenous levels of p-c-Kit protein, only when phosphorylated at Tyr721.

Réactivité croisée (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity chromatography

Pureté: > 95 % by SDS-PAGE

Information d'application

Indications d'application: Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur KIT

Antigène: KIT (Mast/stem Cell Growth Factor Receptor (KIT))

Autre désignation: CD117 / C-Kit

Sujet: The c-Kit proto-oncogene has been identified as a member of the receptor tyrosine kinase family and more specifically has been shown to be closely related to the platelet derived growth factor receptor (PDGFR). c-Kit, the normal cellular homolog of the HZ4-feline sarcoma virus transforming gene v-Kit, encodes a transmembrane receptor with a molecular weight of 145- 160 kDa. c-Kit has also been show to be identical with the product of the W locus in mice and as such is integral to the development of mast cells and hematopoiesis. The ligand for the c-Kit receptor (KL) has been identified and shown to be encoded at the murine steel (SI) locus. Two sites on c-Kit are able to bind SH2(CHK), the Tyr 568/570 diphosphorylated sequence and the monophosphorylated Tyr 721 sequence.Synonyms: KIT, Mast/stem cell growth factor receptor, Proto-Oncogene Tyrosine-Protein Kinase, SCFR

Poids moléculaire: approx. 120,145 kDa

ID gène: 3815

NCBI Accession: NP_000213

UniProt: P10721

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Sensory Perception of Sound, Stem Cell Maintenance, Production of Molecular Mediator of Immune Response, Regulation of long-term Neuronal Synaptic Plasticity