GRAP2 anticorps

N° du produit ABIN499081

Détail du produit anti-GRAP2 anticorps

Antigène: GRAP2 (GRB2-Related Adaptor Protein 2 (GRAP2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GRAP2 est non-conjugé

Application: Western Blotting (WB)

Specificité: This antibody detects endogenous levels of GRAP2 protein. (region surrounding asn158)

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: Affinity chromatography using epitope-specific immunogen

Pureté: > 95 % pure by SDS-PAGE

Information d'application

Indications d'application: Western blot: 1: 500 - 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2, 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur GRAP2

Antigène: GRAP2 (GRB2-Related Adaptor Protein 2 (GRAP2))

Autre désignation: GRAP2 (GRAP2 Produits)

Synonymes: anticorps GADS, anticorps GRAP-2, anticorps GRB2L, anticorps GRBLG, anticorps GRID, anticorps GRPL, anticorps GrbX, anticorps Grf40, anticorps Mona, anticorps P38, anticorps Gads, anticorps GrpL, anticorps zgc:112091, anticorps GRAP2, anticorps grap2, anticorps zgc:65942, anticorps GRB2-related adaptor protein 2, anticorps GRB2-related adaptor protein 2a, anticorps GRB2-related adaptor protein 2b, anticorps GRAP2, anticorps Grap2, anticorps grap2a, anticorps grap2, anticorps grap2b

Sujet: In general, it exists in association with catalytic domains, as in the nonreceptor protein-tyrosine kinases and phospholipase C-γ, within structural proteins, such as spectrin or myosin, and in small adapter proteins, such as Crk and GRB2. SH3 domains are often accompanied by SH2 domains of 100 amino acids that bind to tyrosine-phosphorylated regions of target proteins, frequently linking activated growth factors to putative signal transduction proteins. Deletion or mutation of SH3 domains generally activates the transforming potential of nonreceptor tyrosine kinases, suggesting that SH3 mediates negative regulation of an intrinsic transforming activity. Gads is an adapter proteins that contains both SH2 and SH3 domains. Gads binds to tyrosine-phosphorylated proteins, such as Shc, and functions to couple these proteins to downstream effectors.Synonyms: Adapter protein GRID, GADS, GRB-2-like protein, GRB2-related adapter protein 2, GRB2L, GRBLG, GRBX, GRID, Grf-40, Grf40 adapter protein, Growth factor receptor-binding protein, Hematopoietic cell-associated adapter protein GrpL, SH3-SH2-SH3 adapter Mona

Poids moléculaire: approx. 38 kDa

ID gène: 9402

NCBI Accession: NP_004801

UniProt: O75791

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway