TNIP3 anticorps (C-Term)

N° du produit ABIN499187

Détail du produit anti-TNIP3 anticorps

Antigène: TNIP3 (TNFAIP3 Interacting Protein 3 (TNIP3))

Épitope: C-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TNIP3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: This antibody reactcs to ABIN3 near the carboxy terminus.

Purification: Affinity chromatography purified via peptide column

Immunogène: ABIN3 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human ABIN3.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: ABIN3 antibody can be used for detection of ABIN3 at 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur TNIP3

Antigène: TNIP3 (TNFAIP3 Interacting Protein 3 (TNIP3))

Autre désignation: TNIP3 (TNIP3 Produits)

Synonymes: anticorps ABIN-3, anticorps LIND, anticorps 9030611K07Rik, anticorps TNIP3, anticorps TNFAIP3 interacting protein 3, anticorps TNIP3, anticorps Tnip3

Sujet: The nuclear factor NF-kB plays key roles in development and immunity. ABIN3 (A20-binding inhibitor of NF-kB activation 3), also known as TNFAIP3-interacting protein 3 (TNIP3), is a novel negative feedback regulator of LPS-induced NF-kB activation. ABIN3 is a 39 kDa protein that negatively regulates NF-kB activation in response to TNF and LPS. ABIN3 is highly expressed in brain, thymus, lymph node, lung and fetal liver, with low expression in kidney, bone marrow. Through its interaction with A20, ABIN3 interferes with TRAF2-mediated transactivation signals and NF-kB inhibition is mediated by the ABIN-homology domain 2. ABIN3 has been found to be induced by Listeria infection and can be slightly downregulated by dexamethasone. Enhanced expression of ABIN3 in monocytes is associated with sepsis. Thus, ABIN3 is an IL-10-induced gene product capable of attenuating NF-kB in human macrophages yet is inoperative in mice and represents a basis for species-specific differences in IL-10 actions. At least four isoforms of ABIN3 are known to exist.Synonyms: A20-binding inhibitor of NF-kappa-B activation 3, ABIN-3, ABIN3, LIND, Listeria-induced gene protein, TNFAIP3-interacting protein 3

ID gène: 79931

NCBI Accession: NP_079149

UniProt: Q96KP6

Pathways: Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin