AP2M1 anticorps (C-Term)

N° du produit ABIN499285

Cet anticorps Poulet Polyclonal détecte spécifiquement AP2M1 dans WB, IHC (p) et EIA. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour AP2M1 anticorps (C-Term) (ABIN499285)

Antigène: AP2M1 (Adaptor-Related Protein Complex 2, mu 1 Subunit (AP2M1))

Reactivité: Humain, Souris, Rat

Hôte: Poulet

Clonalité: Polyclonal

Conjugué: Cet anticorp AP2M1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Détail du produit anti-AP2M1 anticorps

Épitope: C-Term

Specificité: This antibody reacts to AP2M1.

Purification: Affinity chromatography purified via peptide column

Immunogène: AP2M1 antibody was raised against a 16 amino acid peptide near the carboxy terminus of human AP2M1.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: AP2M1 antibody can be used for detection of AP2M1 at 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur AP2M1

Antigène: AP2M1 (Adaptor-Related Protein Complex 2, mu 1 Subunit (AP2M1))

Sujet: The heterotetrameric coat assembly protein complex, also known as the adaptor-related protein complex 2 (AP-2), belongs to the adaptor complexes medium subunits family. The mu 1 subunit of the AP-2 complex (AP2M1) is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. AP2M1 has also been shown to associate with the HIV-1 protein Nef, suggesting that Nef may use AP-2 complex to enhance the rate of endocytosis of both CD4 and class I MHC. AP2M1 may also play an important role in regulating the intracellular trafficking and function of cytotoxic T-lymphocyte associated (CTLA)-4 protein. At least two isoforms of AP2M1 are known to exist.Synonyms: AP-2 mu-2 chain, Adaptin-mu2, CLAPM1, Clathrin assembly protein complex 2 medium chain, Clathrin coat assembly protein AP50, Clathrin coat-associated protein AP5, HA2 50 kDa subunit, KIAA0109, Plasma membrane adaptor AP-2 50 kDa protein

ID gène: 1173

NCBI Accession: NP_004059

UniProt: Q96CW1

Pathways: EGFR Signaling Pathway, Neurotrophin Signaling Pathway, EGFR Downregulation, SARS-CoV-2 Protein Interactome