Caspase 1 anticorps (Intermediate Domain)

N° du produit ABIN499543

Détail du produit anti-Caspase 1 anticorps

Antigène: Caspase 1 (CASP1)

Épitope: Intermediate Domain

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Caspase 1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: Caspase-1 antibody was raised against a 15 amino acid peptide from near the middle of human Caspase-1.

Purification: Affinity chromatography purified via peptide column

Immunogène: Human Casp-1 / ICE / IL-1b converting enzyme (Intermediate Domain) Peptide

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: Casp-1 antibody can be used for the detection of Caspase-1 at 0.5 μg/mL. Depending on cell lines or tissues used, other cleavage products may be observed. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur Caspase 1

Antigène: Caspase 1 (CASP1)

Autre désignation: Caspase-1 (CASP1 Produits)

Synonymes: anticorps ICE, anticorps IL1BC, anticorps P45, anticorps Il1bc, anticorps Ice, anticorps CASP1, anticorps CG5370, anticorps DCP-1, anticorps DCP1, anticorps Dcp1, anticorps Dmel\\CG5370, anticorps ccp1, anticorps dcp-1, anticorps dcp1, anticorps l(2)01862, anticorps l(2)02132, anticorps caspase 1, anticorps caspase 1, apoptosis-related cysteine peptidase, anticorps caspase 4, apoptosis-related cysteine peptidase, anticorps Death caspase-1, anticorps caspase-1, anticorps caspase, anticorps caspase recruitment domain-containing protein 16, anticorps caspase 4, anticorps CASP1, anticorps Casp1, anticorps CASP4, anticorps Dcp-1, anticorps Caspase1, anticorps LOC5564196, anticorps LOC451519

Sujet: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens (reviewed in 1 and 2). Members of this subfamily include caspase-1, -4, -5, and -12 and can activate proinflammatory cytokines such as IL-1beta and IL-18 (3,4). Caspase-1 was initially identified as an IL-1beta-converting enzyme (5), later experiments revealed it to be a mammalian homolog of the C. elegans cell death gene ced-3 (6) whose overexpression can induce apoptosis in fibroblasts (7).Synonyms: CASP-1, CASP1, ICE, IL1BC, IL1BCE, Interleukin-1 beta convertase, Interleukin-1 beta-converting enzyme, p45

ID gène: 834

NCBI Accession: NP_150634

UniProt: P29466

Pathways: Apoptose, Interferon-gamma Pathway, Positive Regulation of Endopeptidase Activity, Inflammasome