Caspase 2 anticorps (N-Term)

N° du produit ABIN499559

L’anticorps anti-Caspase 2 Polyclonal Lapin est utilisé pour la détection de Caspase 2 dans des échantillons de Humain et Souris. Il a été validé pour WB, IF et EIA.

Aperçu rapide pour Caspase 2 anticorps (N-Term) (ABIN499559)

Antigène: Caspase 2 (CASP2) (Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Caspase 2 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Détail du produit anti-Caspase 2 anticorps

Épitope: N-Term

Specificité: Caspase-2 antibody was raised against a 16 amino acid peptide from the amino-terminus of human Caspase-2.

Purification: Affinity chromatography purified via peptide column

Immunogène: Murine Casp-2 / ICH-1 / Nedd2 (N-Terminus) Peptide

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: Caspase-2 antibody can be used for the detection of caspase-2 at 1 μg/mL. Depending on cell lines or tissues used, other cleavage products may be observed. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur Caspase 2

Antigène: Caspase 2 (CASP2) (Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2))

Autre désignation: Caspase-2

Sujet: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens (reviewed in 1 and 2). Members of this subfamily include caspase-1, -4, -5, and -12 and can activate proinflammatory cytokines such as IL-1beta and IL-18 (3,4). Although phylogenetically similar to this subfamily, Caspase-2 is thought to be involved in stress-induced apoptosis (5). Caspase-2 has two major isoforms, overexpression on the long form results in apoptosis while that of the short form suppresses cell death (6).Synonyms: CASP-2, CASP2, ICH-1 protease, ICH1, NEDD2, Neural precursor cell expressed developmentally down-regulated protein 2

ID gène: 835

UniProt: P42575

Pathways: Apoptose, Caspase Cascade in Apoptosis, Neurotrophin Signaling Pathway