Caspase 4 anticorps (Intermediate Domain)

N° du produit ABIN499563

Cet anticorps anti-Caspase 4 Polyclonal Lapin (ABIN499563) détecte spécifiquement Caspase 4 dans WB, IHC (p) et EIA. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Caspase 4 anticorps (Intermediate Domain) (ABIN499563)

Antigène: Caspase 4 (CASP4) (Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Caspase 4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Détail du produit anti-Caspase 4 anticorps

Épitope: Intermediate Domain

Specificité: Caspase-4 antibody was raised against a 15 amino acid peptide from near the center of human Caspase-4.

Purification: Affinity chromatography purified via peptide column

Immunogène: Human Casp-4 / ICH-2 / ICE rel II / Mih1 (Intermediate Domain) Peptide

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: Casp-4 antibody can be used for the detection of Caspase-4 at 2 μg/mL. Depending on cell lines or tissues used, other cleavage products may be observed. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur Caspase 4

Antigène: Caspase 4 (CASP4) (Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4))

Autre désignation: Caspase-4

Sujet: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens (reviewed in 1). Members of this subfamily include caspase-1, -4, -5, and -12. Activation of these caspases results in the cleavage and activation of proinflammatory cytokines such as IL-1beta and IL-18 (2,3). Caspase-4 was initially identified as a homologous protein to Caspase-1 and the C. elegans Ced-3 which could induce apoptosis in transfected cells (4). More recent studies have shown that it can be activated by ER stress and has been suggested to be involved in multiple neuronal pathologies such as Alzheimers disease (5).Synonyms: CASP4, ICE(rel)-II, ICH2, Protease ICH-2, Protease TX

ID gène: 837

UniProt: P49662

Pathways: Apoptose, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity