CASP5 anticorps (Intermediate Domain)

N° du produit ABIN499567

Cet anticorps Lapin Polyclonal détecte spécifiquement CASP5 dans WB, IF et EIA. Il présente une réactivité envers Humain.

Aperçu rapide pour CASP5 anticorps (Intermediate Domain) (ABIN499567)

Antigène: CASP5 (Caspase 5, Apoptosis-Related Cysteine Peptidase (CASP5))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CASP5 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Détail du produit anti-CASP5 anticorps

Épitope: Intermediate Domain

Specificité: Caspase-5 antibody was raised against a 14 amino acid peptide from the center of human Caspase-5.

Purification: Affinity chromatography purified via peptide column

Immunogène: Human Casp-5 / (ICH-3 / ICE rel III (Intermediate Domain) Peptide

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: Casp-5 antibody can be used for the detection of caspase-5 at 0.5 - 1 μg/mLDepending on cell lines or tissues used, other cleavage products may be observed. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur CASP5

Antigène: CASP5 (Caspase 5, Apoptosis-Related Cysteine Peptidase (CASP5))

Autre désignation: Caspase-5

Sujet: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens (reviewed in 1). Members of this subfamily include caspase-1, -4, -5, and -12. Activation of these caspases results in the cleavage and activation of proinflammatory cytokines such as IL-1beta and IL-18 (2,3). Caspase-5 can interact with caspase-1, both are constituents of the NALP1 inflammasome, a complex that can trigger the cleavage of pro-IL-1beta (4). Expression of caspase-5 can be regulated by lipopolysaccharide (LPS) and IFN-gamma (5).Synonyms: CASP-5, CASP5, ICE(rel)-III, ICH-3 protease, ICH3, TY protease

ID gène: 838

UniProt: P51878

Pathways: Inflammasome