UBQLN4 anticorps (N-Term)

N° du produit ABIN499635

Cet anticorps anti-UBQLN4 est un anticorps Lapin Polyclonal détectant UBQLN4 dans WB, IHC (p) et EIA. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour UBQLN4 anticorps (N-Term) (ABIN499635)

Antigène: UBQLN4 (Ubiquilin 4 (UBQLN4))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp UBQLN4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Détail du produit anti-UBQLN4 anticorps

Épitope: N-Term

Specificité: This antibody reacts to CIP75.

Purification: Affinity chromatography purified via peptide column

Immunogène: CIP75 antibody was raised against an 18 amino acid peptide near the amino terminus of human CIP75.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: CIP75 antibody can be used for detection of CIP75 at 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur UBQLN4

Antigène: UBQLN4 (Ubiquilin 4 (UBQLN4))

Autre désignation: Ubiquilin-4

Sujet: The ubiquitin-proteosome pathway of protein degradation is one of the mechanisms that ensure the proper level of cellular proteins. The ubiquitin-like (UbL) and ubiquitin-associated (UBA) domain containing protein family is thought to be involved in proteosomal degradation. One such protein is CIP75, also known as ubiquilin-4, interacts with a number of proteins such as Ataxin-1 and Connexin-43, resulting in an increased rate of turnover of these proteins. Overexpression CIP75 led to a significant reduction of Connexin-43 half-life, with the opposite being observed in siRNA knockdown experiments. CIP75 contains an N-terminal UbL domain which is thought to interact with proteins of the 26S proteosome complex and a C-terminal UBA domain which appears to mediate its interaction with Connexin-75. At least three isoforms of CIP75 are known to exist.Synonyms: A1Up, Ataxin-1 interacting ubiquitin-like protein, Ataxin-1 ubiquitin-like-interacting protein A1U, C1orf6, CIP75, Connexin43-interacting protein of 75 kDa, UBIN, UBQLN4

ID gène: 56893

UniProt: Q9NRR5