BCAR1 anticorps (pTyr249) (AbBy Fluor® 680)

N° du produit ABIN4997236

L’anticorps Lapin Polyclonal anti-BCAR1 a été validé pour IF (cc) et IF (p). Il convient pour détecter BCAR1 dans des échantillons de Humain.

Aperçu rapide pour BCAR1 anticorps (pTyr249) (AbBy Fluor® 680) (ABIN4997236)

Antigène: BCAR1 (Breast Cancer Anti-Estrogen Resistance 1 (BCAR1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BCAR1 est conjugé à/à la AbBy Fluor® 680

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-BCAR1 anticorps (AbBy Fluor® 680)

Épitope: pTyr249

Homologie: Human

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from human BCAR1 around the phosphorylation site of Tyr249

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur BCAR1

Antigène: BCAR1 (Breast Cancer Anti-Estrogen Resistance 1 (BCAR1))

Autre désignation: BCAR1

Sujet:

Synonyms: BCAR1 phospho Y249, BCAR1phospho Y249, p-BCAR1p-Tyr249, Breast cancer anti estrogen resistance 1 protein, BCAR 1, Bcar1, BCAR1_HUMAN, Breast cancer anti estrogen resistance 1, Breast cancer anti-estrogen resistance protein 1, CAS, Cas scaffolding protein family member 1, Crk associated substrate, Crk associated substrate p130Cas, CRK-associated substrate, CRKAS, P130CAS.

Background: p130 represents one of several known substrates for v-Crk encoded p47. p130 Cas (for Crk-associated substrate) exhibits a high level of tyrosine phosphorylation and is tightly associated with v-Crk, suggesting a role in v-Crk-mediated cell signaling. The molecular cloning of p130 Cas has shown it to represent a novel SH3 containing signaling molecule with a cluster of multiple putative SH2-binding motifs for v-Crk. By immunoprecipitation analysis, p130 Cas has been shown to be highly phosphorylated at tyrosine residues subsequent to either v-Src p60 or v-Crk-mediated transformation and to form stable complexes with both of these transforming proteins. p130 Cas behaves as an extremely potent substrate for protein tyrosine kinases and has been reported to relocate from the cytoplasm to cell membrane upon tyrosine phosphorylation. One proposed model is that the SH2 domain of v-Crk functions to activate c-Src kinase, which in turn phosphorylates p130 Cas.

ID gène: 9564

Pathways: EGFR Signaling Pathway, Neurotrophin Signaling Pathway, CXCR4-mediated Signaling Events, Platelet-derived growth Factor Receptor Signaling