Beclin 1 anticorps (AA 160-190) (FITC)

N° du produit ABIN4997341

L’anticorps Souris Monoclonal anti-Beclin 1 a été validé pour WB et IF (p). Il convient pour détecter Beclin 1 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Beclin 1 anticorps (AA 160-190) (FITC) (ABIN4997341)

Antigène: Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Beclin 1 est conjugé à/à la FITC

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Clone: 7B12

Détail du produit anti-Beclin 1 anticorps (FITC)

Épitope: AA 160-190

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein G.

Immunogène: KLH conjugated synthetic peptide derived from human Beclin 1

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur Beclin 1

Antigène: Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))

Autre désignation: Beclin 1

Sujet:

Synonyms: Beclin-1, BECN1, Coiled-coil myosin-like BCL2-interacting protein, Protein GT197

Background: Plays a central role in autophagy (PubMed:23184933). Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate, different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis (PubMed:25275521). Protects against infection by a neurovirulent strain of Sindbis virus (PubMed:9765397). May play a role in antiviral host defense. Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis, it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.

ID gène: 8678

UniProt: Q14457

Pathways: Autophagy