ECSIT anticorps (C-Term)

N° du produit ABIN499780

Cet anticorps Lapin Polyclonal détecte spécifiquement ECSIT dans WB, EIA et IHC (p). Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour ECSIT anticorps (C-Term) (ABIN499780)

Antigène: ECSIT

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ECSIT est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-ECSIT anticorps

Épitope: C-Term

Specificité: ECSIT antibody was raised against a peptide corresponding to 14 amino acids near the C-terminus of human ECSIT.

Purification: Ion exchange chromatography

Immunogène: Human ECSIT (C-Terminus) Peptide

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 0.5 to 1 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur ECSIT

Antigène: ECSIT

Autre désignation: ECSIT

Sujet: Activation of NF-?B as a result of Toll-like receptor (TLR) and IL-1 receptor signaling is a major component of innate immune responses (reviewed in 1). Signals from these receptors are relayed by a number of adapter molecules such as TRIF, TIRAP, and MyD88 (2) to kinases such as IRAK (3) and other intermediates such as TNF receptor associated factor (TRAF)-6 (4). ECSIT (evolutionarily conserved signaling intermediate in Toll pathways) was initially identified as a cytoplasmic protein interacting specifically with TNF receptor associated factor (TRAF)-6 in the TLR pathway (5). Recently however, ECSIT has also been shown to be required for bone morphogenetic protein (Bmp) signaling and mesoderm formation during mouse embryogenesis (6), indicating the possibility of cross-talk between the TLR/IL-B and Bmp signaling pathways.Synonyms: ECSIT homolog (Drosophila), Evolutionarily conserved signaling intermediate in Toll pathway, SITPEC, Signaling intermediate in toll pathway evolutionarily conserved, mitochondrial

ID gène: 51295

NCBI Accession: NP_057665

UniProt: Q9BQ95

Pathways: Signalisation TLR, Toll-Like Receptors Cascades, SARS-CoV-2 Protein Interactome