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Integrin alpha 4 (ITGA4) (Center) anticorps Primary Antibody

ITGA4 Reactivité: Humain, Souris, Rat EIA, IF, WB Hôte: Lapin Polyclonal
Pubmed (1)
N° du produit ABIN500032
$511.50
Plus shipping costs $45.00
0.1 mg
local_shipping Destination: Etats-Unis
Envoi sous 6 à 8 jours ouvrables
  • Antigène
    Épitope
    Center
    Reactivité
    Humain, Souris, Rat
    Hôte
    Lapin
    Clonalité
    Polyclonal
    Conjugué
    Inconjugué
    Application
    Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
    Specificité
    This antibody reacts to Integrin alpha 4.
    Purification
    Affinity chromatography purified via peptide column
    Immunogène
    Integrin alpha 4 antibody was raised against a 15 amino acid peptide from near the center of human Integrin alpha 4.
    Isotype
    IgG
  • Indications d'application
    ELISA. Western Blot: 0.5 - 1 μg/mL. Immunofluorescence.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C.
  • Gąciarz, Ruddock: "Complementarity determining regions and frameworks contribute to the disulfide bond independent folding of intrinsically stable scFv." dans: PLoS ONE, Vol. 12, Issue 12, pp. e0189964, 2018 (PubMed).

  • Antigène
    Autre désignation
    CD49d / ITGA4 (ITGA4 Antibody Extrait)
    Synonymes
    CD49D, IA4, LOC100219853, integrin subunit alpha 4, integrin alpha 4, integrin subunit alpha 4 S homeolog, ITGA4, Itga4, itga4.S
    Sujet
    The integrin alpha 4 (also known as CD49d and ITGA4) belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha and beta chains. Alpha 4 chain associates with either beta 1 or beta 7 chain. It has been demonstrated that the putative ligand-binding sites of both integrin alpha 4 beta 1 and alpha 4 beta 7 is located on the alpha 4 chain. These ligands included Madcam, VCAM, and fibronectin. Madcam is known as the principal ligand for integrin alpha 4 beta 7. Recently it was also demonstrated that HIV-1 envelope can mimic Madcam by binding to and signaling though integrin alpha 4 beta 7, the gut mucosal homing receptor for peripheral T cells. Despite its predicted molecular weight, Integrin alpha 4 will often run at higher molecular weight in SDS-PAGE. At least two isoforms are known to exist. The immunogen to this antibody is within the Integrin alpha 4 recombinant protein fragment and thus will recognize it.Synonyms: CD49 antigen-like family member D, Integrin alpha-4, Integrin alpha-IV, VLA-4, VLA4
    ID gène
    3676
    UniProt
    P13612
    Pathways
    Integrin Complex
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