POLI anticorps (AA 51-150) (AbBy Fluor® 680)

N° du produit ABIN5001357

Cet anticorps Lapin Polyclonal détecte spécifiquement POLI dans IF (cc) et IF (p). Il présente une réactivité envers Rat.

Aperçu rapide pour POLI anticorps (AA 51-150) (AbBy Fluor® 680) (ABIN5001357)

Antigène: POLI (Polymerase (DNA Directed) iota (POLI))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp POLI est conjugé à/à la AbBy Fluor® 680

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-POLI anticorps (AbBy Fluor® 680)

Épitope: AA 51-150

Réactivité croisée: Rat

Homologie: Human,Mouse,Dog

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human DNA Polymerase iota

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur POLI

Antigène: POLI (Polymerase (DNA Directed) iota (POLI))

Autre désignation: DNA Polymerase iota

Sujet:

Synonyms: DNA polymerase iota, Eta 2, Eta2, POLI, POLI_HUMAN, Polymerase DNA directed iota, RAD 30B, RAD30 homolog B, RAD30B, RAD3OB.

Background: DNA polymerase activity is essential for replication, repair, recombination and mutagenesis. DNA polymerases can often bypass DNA lesions that block DNA replication, thereby allowing the replication of damaged DNA. One such DNA polymerase is the distributive enzyme DNA Pol i, which is encoded by the POLI gene. POLI is located on human chromosome 18q21.2, a region often implicated in the etiology of many human cancers. At thymine templates, DNA Pol i is highly error-prone when replicating undamaged DNA in that it favors the misincorporation of guanine over the correct nucleotide, adenosine. DNA Pol i also promotes the replication of damaged DNA by misincorporating deoxynucleotides opposite DNA lesions. DNA Pol i acts sequentially with DNA Pol , which is essential for damage-induced mutagenesis, to complete the DNA lesion bypass. Therefore, replication involving DNA Pol i is likely to be highly mutagenic.

ID gène: 11201

Pathways: Réparation de l'ADN