LDLR anticorps (Center)

N° du produit ABIN500146

Cet anticorps Poulet Polyclonal détecte spécifiquement LDLR dans WB, IHC (p) et EIA. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour LDLR anticorps (Center) (ABIN500146)

Antigène: LDLR (Low Density Lipoprotein Receptor (LDLR))

Reactivité: Humain, Souris, Rat

Hôte: Poulet

Clonalité: Polyclonal

Conjugué: Cet anticorp LDLR est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Détail du produit anti-LDLR anticorps

Épitope: Center

Specificité: This antibody detects LDL-R.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat

Purification: Peptide affinity chromatography

Immunogène: LDL-R antibody was raised against an 18 amino acid peptide near the center of human LDL- R.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur LDLR

Antigène: LDLR (Low Density Lipoprotein Receptor (LDLR))

Autre désignation: LDLR

Sujet: The low density lipoprotein receptor (LDL-R) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in the LDL-R gene cause the autosomal dominant disorder, familial hypercholesterolemia. Along with SCARB1, CLDN1, and the tetraspanin superfamily member CD81, LDL-R has been reported to be an entry factor for the Hepatitis C virus. At least three isoforms of LDL-R are known to exist.Synonyms: LDL receptor, LDLR, Low-density lipoprotein receptor

ID gène: 3949

NCBI Accession: NP_000518

UniProt: P01130

Pathways: Hepatitis C, Lipid Metabolism