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LDLR anticorps (Center)

LDLR Reactivité: Humain, Souris, Rat WB, IHC (p), EIA Hôte: Poulet Polyclonal unconjugated
N° du produit ABIN500146
  • Antigène Voir toutes LDLR Anticorps
    LDLR (Low Density Lipoprotein Receptor (LDLR))
    Épitope
    • 16
    • 6
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Center
    Reactivité
    • 75
    • 40
    • 26
    • 17
    • 16
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 64
    • 11
    • 4
    Poulet
    Clonalité
    • 62
    • 17
    Polyclonal
    Conjugué
    • 44
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp LDLR est non-conjugé
    Application
    • 58
    • 32
    • 27
    • 19
    • 13
    • 8
    • 7
    • 7
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificité
    This antibody detects LDL-R.
    Réactivité croisée (Details)
    Species reactivity (tested):Human, mouse, rat
    Purification
    Peptide affinity chromatography
    Immunogène
    LDL-R antibody was raised against an 18 amino acid peptide near the center of human LDL- R.
    Isotype
    IgG
    Top Product
    Discover our top product LDLR Anticorps primaire
  • Indications d'application
    ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Antigène
    LDLR (Low Density Lipoprotein Receptor (LDLR))
    Autre désignation
    LDLR (LDLR Produits)
    Synonymes
    anticorps FH, anticorps FHC, anticorps LDLCQ2, anticorps Hlb301, anticorps LDLRA, anticorps LDLA, anticorps LDL receptor-2, anticorps fhc, anticorps ldlcq2, anticorps ldlr, anticorps ldlr2-a, anticorps LDL receptor 1, anticorps ldlr-a, anticorps ldlr-b, anticorps low density lipoprotein receptor, anticorps low density lipoprotein receptor a, anticorps low density lipoprotein receptor S homeolog, anticorps low density lipoprotein receptor L homeolog, anticorps LDLR, anticorps Ldlr, anticorps ldlra, anticorps ldlr.S, anticorps ldlr.L
    Sujet
    The low density lipoprotein receptor (LDL-R) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in the LDL-R gene cause the autosomal dominant disorder, familial hypercholesterolemia. Along with SCARB1, CLDN1, and the tetraspanin superfamily member CD81, LDL-R has been reported to be an entry factor for the Hepatitis C virus. At least three isoforms of LDL-R are known to exist.Synonyms: LDL receptor, LDLR, Low-density lipoprotein receptor
    ID gène
    3949
    NCBI Accession
    NP_000518
    UniProt
    P01130
    Pathways
    Hepatitis C, Lipid Metabolism
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