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Transportin 1 anticorps (N-Term)

TNPO1 Reactivité: Humain, Souris, Rat WB, IHC (p), EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN500230
  • Antigène Voir toutes Transportin 1 (TNPO1) Anticorps
    Transportin 1 (TNPO1)
    Épitope
    • 8
    • 7
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 40
    • 21
    • 18
    • 1
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 37
    • 4
    • 1
    Lapin
    Clonalité
    • 38
    • 4
    Polyclonal
    Conjugué
    • 17
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Transportin 1 est non-conjugé
    Application
    • 40
    • 19
    • 17
    • 14
    • 13
    • 6
    • 5
    • 4
    • 3
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificité
    This antibody detects MIP1 at N-term.
    Réactivité croisée (Details)
    Species reactivity (tested):Human, mouse, rat
    Purification
    Peptide affinity chromatography
    Immunogène
    MAPKAP1 antibody was raised against a 19 amino acid peptide from near the amino terminus of human MAPKAP1.
    Isotype
    IgG
    Top Product
    Discover our top product TNPO1 Anticorps primaire
  • Indications d'application
    ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistry on paraffin sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Antigène
    Transportin 1 (TNPO1)
    Autre désignation
    MIP1 (TNPO1 Produits)
    Synonymes
    anticorps IPO2, anticorps KPNB2, anticorps MIP, anticorps MIP1, anticorps TRN, anticorps TNPO1, anticorps AU021749, anticorps D13Ertd688e, anticorps Kpnb2, anticorps ATTRN1, anticorps F12A24.13, anticorps F12A24_13, anticorps TRANSPORTIN 1, anticorps transportin 1, anticorps DKFZp469O204, anticorps transportin 1, anticorps transportin-1, anticorps transportin 1 S homeolog, anticorps TNPO1, anticorps LOC738932, anticorps tnpo1, anticorps Tnpo1, anticorps tnpo1.S, anticorps TRN1
    Sujet
    MAPKAP1 was initially identified as the human homolog of S. pombe SIN1. Recent evidence has shown that it identical to Mip1, a protein that interacts with MEKK2, a member of the mitogen-activated protein kinase (MAPK) intracellular signaling network. MAPKAP1 is thought to prevent MEKK2 activation and dimerization by forming a complex with the inactive and non-phosphorylated MEKK2, thereby blocking the JNK1/2, ERK1/2, p38 and ERK5 MAPKs. MAPKAP1 has also been shown to play a role in the TOR signaling process, a pathway that is involved in controlling cell growth and proliferation in response to environmental cues such as nutrients, growth factors and hormones. Experiments showed that MAPKAP1 helped to maintain the TOR/rictor assembly but not the TOR/RAPTOR complex, which allowed specific phosphorylation of Akt, a kinase that is believed to couple the growth factor-PI3K signaling pathway to the nutrient-regulated TOR signaling pathway. Multiple alternatively spliced isoforms of MAPKAP1 have been identified.Synonyms: MAPKAP1, Mitogen-activated protein kinase 2-associated protein 1, SAPK-interacting protein 1, SIN1, Stress-activated map kinase-interacting protein 1, TORC2 subunit MAPKAP1, Target of rapamycin complex 2 subunit MAPKAP1, mSIN1
    ID gène
    79109
    NCBI Accession
    NP_001006618
    UniProt
    Q9BPZ7
    Pathways
    Signalisation PI3K-Akt, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Cellular Glucan Metabolic Process, Protein targeting to Nucleus, CXCR4-mediated Signaling Events
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