NAIP anticorps (C-Term)

N° du produit ABIN500306

L’anticorps Lapin Polyclonal anti-NAIP a été validé pour WB, IF et EIA. Il convient pour détecter NAIP dans des échantillons de Humain.

Aperçu rapide pour NAIP anticorps (C-Term) (ABIN500306)

Antigène: NAIP (NLR Family, Apoptosis Inhibitory Protein (NAIP))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NAIP est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Détail du produit anti-NAIP anticorps

Épitope: C-Term

Specificité: This antibody detects NAIP at C-term.

Réactivité croisée (Details): Species reactivity (tested):Human

Purification: Peptide affinity chromatography

Immunogène: NAIP antibody was raised against a synthetic peptide corresponding to 13 amino acids at the C-terminus of human NAIP.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 0.5 to 1 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur NAIP

Antigène: NAIP (NLR Family, Apoptosis Inhibitory Protein (NAIP))

Autre désignation: NAIP

Sujet: Neuronal apoptosis inhibitor protein (NAIP) was the first human inhibitor of apoptosis protein (IAP) identified and was discovered by its association with the neurodegenerative disorder spinal muscular atrophy (1,2). Members of the IAP family contain one to three copies of an approximately 70 amino acid motif termed baculovirus IAP repeat (BIR), these BIRs promote protein-protein interactions with various caspases such as caspase-3, -7, and -9 as well as members of the TRAF family of signal molecules (reviewed in 3). Unlike other IAPs however, NAIP requires ATP to bind caspase-9 and is not inhibited by the IAP-inhibiting molecule Smac/DIABLO (4), suggesting that NAIP is unique among the IAPs in its regulation of its activity. Finally, although only one human NAIP protein has been identified, other shorter NAIP mRNA transcripts have been reported (5).Synonyms: BIRC1, Baculoviral IAP repeat-containing protein 1

ID gène: 4671

UniProt: Q13075

Pathways: Apoptose, Inflammasome