ORAI1 anticorps (N-Term)

N° du produit ABIN500419

Cet anticorps Lapin Polyclonal détecte spécifiquement ORAI1 dans WB, IHC (p) et EIA. Il présente une réactivité avec des échantillons de Humain et Souris.

Aperçu rapide pour ORAI1 anticorps (N-Term) (ABIN500419)

Antigène: ORAI1 (ORAI Calcium Release-Activated Calcium Modulator 1 (ORAI1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ORAI1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Détail du produit anti-ORAI1 anticorps

Épitope: N-Term

Specificité: This antibody detects ORAI1 at N-term. It is predicted to have no cross-reactivity to ORAI2 or ORAI3.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse

Purification: Peptide affinity chromatography

Immunogène: ORAI1 antibody was raised against a 18 amino acid peptide from near the amino terminus of human ORAI1.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur ORAI1

Antigène: ORAI1 (ORAI Calcium Release-Activated Calcium Modulator 1 (ORAI1))

Autre désignation: ORAI1

Sujet: Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI1 is a recently identified four-transmembrane spanning protein that is an essential component of CRAC. A missense mutation in this protein in humans is the cause of one form of hereditary severe combined immune deficiency (SCID) which results in ablated T-cell Ca++ entry. It has been suggested that ORAI1 functions as a highly selective Ca++ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. ORAI1 often migrates at a higher than expected molecular weight in SDS-PAGE.Synonyms: CRACM1, Calcium release-activated calcium channel protein 1, ORAI-1, Protein orai-1, TMEM142A, Transmembrane protein 142A

ID gène: 84876

UniProt: Q96D31

Pathways: TCR Signaling, BCR Signaling