ORAI1 anticorps (C-Term)

N° du produit ABIN500421

Détail du produit anti-ORAI1 anticorps

Antigène: ORAI1 (ORAI Calcium Release-Activated Calcium Modulator 1 (ORAI1))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ORAI1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: This antibody detects ORAI1 at C-term. It is predicted to have no cross-reactivity to ORAI2 or ORAI3.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat

Purification: Peptide affinity chromatography

Immunogène: ORAI1 antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human ORAI1.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur ORAI1

Antigène: ORAI1 (ORAI Calcium Release-Activated Calcium Modulator 1 (ORAI1))

Autre désignation: ORAI1 (ORAI1 Produits)

Synonymes: anticorps CRACM1, anticorps ORAT1, anticorps TMEM142A, anticorps RGD1311873, anticorps D730049H07Rik, anticorps Tmem142a, anticorps orai-1, anticorps im:7146264, anticorps orai1, anticorps tmem142a, anticorps zgc:109721, anticorps orai2, anticorps ORAI1, anticorps LOC100218031, anticorps ORAI calcium release-activated calcium modulator 1, anticorps ORAI calcium release-activated calcium modulator 1b, anticorps ORAI calcium release-activated calcium modulator 1 S homeolog, anticorps ORAI1, anticorps Orai1, anticorps orai1b, anticorps orai1.S, anticorps orai1

Sujet: Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI1 is a recently identified four-transmembrane spanning protein that is an essential component of CRAC. A missense mutation in this protein in humans is the cause of one form of hereditary severe combined immune deficiency (SCID) which results in ablated T-cell Ca++ entry. It has been suggested that ORAI1 functions as a highly selective Ca++ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. ORAI1 often migrates at a higher than expected molecular weight in SDS-PAGE.Synonyms: CRACM1, Calcium release-activated calcium channel protein 1, ORAI-1, Protein orai-1, TMEM142A, Transmembrane protein 142A

ID gène: 84876

UniProt: Q96D31

Pathways: TCR Signaling, BCR Signaling