PEN2 anticorps (C-Term)

N° du produit ABIN500471

L’anticorps Lapin Polyclonal anti-PEN2 a été validé pour WB, IF et EIA. Il convient pour détecter PEN2 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour PEN2 anticorps (C-Term) (ABIN500471)

Antigène: PEN2 (PSENEN) (Presenilin Enhancer 2 Homolog (PSENEN))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PEN2 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Détail du produit anti-PEN2 anticorps

Épitope: C-Term

Specificité: This antibody detects PEN2 at C-term.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat

Purification: Peptide affinity chromatography

Immunogène: PEN2 antibody was raised against a 13 amino acid peptide from near the carboxy terminus of human PEN2.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot. Immunoflourescence.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur PEN2

Antigène: PEN2 (PSENEN) (Presenilin Enhancer 2 Homolog (PSENEN))

Autre désignation: PEN2

Sujet: PEN2, in addition to presenilin, nicastrin, and APH-1 forms the γ-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer's disease. Like the tumor necrosis factor-α-converting enzyme (TACE) and the β-site cleavage enzyme (BACE) protease families, γ-secretase will cleave the amyloid precursor protein (APP), but within the intramembrane region of APP, resulting in either the non-toxic p3 (from the α and γ cleavage site) or the toxic A?β amyloid peptide (from the β and γ cleavage site). It is thought that accumulation of the Aβ peptide is the precursor to Alzheimer's disease.Synonyms: Gamma-secretase subunit PEN-2, MDS033, PSENEN, Presenilin enhancer protein 2

ID gène: 55851

NCBI Accession: NP_758844

UniProt: Q9NZ42

Pathways: Signalisation Notch, Neurotrophin Signaling Pathway