Fibrinogen anticorps (AbBy Fluor® 750)

N° du produit ABIN5004973

L’anticorps Souris Monoclonal anti-Fibrinogen a été validé pour IF (p). Il convient pour détecter Fibrinogen dans des échantillons de Humain.

Aperçu rapide pour Fibrinogen anticorps (AbBy Fluor® 750) (ABIN5004973)

Antigène: Fibrinogen

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Fibrinogen est conjugé à/à la AbBy Fluor® 750

Application: Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Clone: 4F7

Détail du produit anti-Fibrinogen anticorps (AbBy Fluor® 750)

Réactivité croisée: Humain

Purification: Purified by Protein G.

Immunogène: Fibrinogen from human plasma

Isotype: IgG1

Information d'application

Indications d'application: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur Fibrinogen

Antigène: Fibrinogen

Autre désignation: human Fibrinogen

Sujet:

Synonyms: FGA, FGA protein, FGB, FGG, Fib2, Fibrin alpha chain ,Fibrinogen A alpha polypeptide, Fibrinogen A alpha polypeptide chain, Fibrinogen alpha chain, Fibrinogen B alpha polypeptide, Fibrinogen beta chain, Fibrinogen G alpha polypeptide, Fibrinogen gamma chain, MGC104327, MGC119422, MGC119423, MGC119425, MGC120405, FIBA_HUMAN.

Background: Fibrinogen is the main protein of blood coagulation system. It is a large protein and it consists of two identical subunits that contain three polypeptide chains: alpha, beta and gamma. All chains are connected with each other by a number of disulfide bonds. Fibrinopeptides A (1 to 16 amino acids) and B (1 to 17 amino acids) are released by thrombin from the N terminal parts of alpha and beta chains, respectively. In this way fibrinogen is converted into fibrin, which by means of polymerization forms a fibrin clot. Fibrinogen clotting underlies pathogenesis of MI, thromboembolism and thromboses of arteries and veins, since fibrin is the main substrate for thrombus formation. Fibrinogen activation is also involved in pathogenesis of inflammation, tumor growth and many other diseases. The normal fibrinogen concentration in plasma is about 3 mg/mL. The elevated level of fibrinogen in patient's blood is regarded as an independent risk factor for cardiovascular diseases. An increase in blood fibrinogen concentration was shown to be a strong predictor of coronary heart disease (Sonel A. et al, and Rapold H.J. et al). All these facts make fibrinogen an important parameter in the diagnosis of cardiovascular diseases.

ID gène: 2243