RIPK2 anticorps (N-Term)

N° du produit ABIN500599

Cet anticorps Lapin Polyclonal détecte spécifiquement RIPK2 dans WB, IF et EIA. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour RIPK2 anticorps (N-Term) (ABIN500599)

Antigène: RIPK2 (Receptor-Interacting Serine-threonine Kinase 2 (RIPK2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RIPK2 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Détail du produit anti-RIPK2 anticorps

Épitope: N-Term

Specificité: This antibody detects RICK at N-term.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat

Purification: Peptide affinity chromatography

Immunogène: RICK antibody was raised against a peptide corresponding to amino acids near the amino terminus of human RICK.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 1: 1000, an approximately 60 kDa band can be detected. Immuoflourescence.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur RIPK2

Antigène: RIPK2 (Receptor-Interacting Serine-threonine Kinase 2 (RIPK2))

Autre désignation: RIPK2

Sujet: Apoptosis is mediated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. DD-containing serine/threonine kinase RIP regulates Fas-induced apoptosis. A novel CARD-containing serine/threonine kinase was recently identified and designated RICK/RIP2/CARDIAK for RIP-like interacting CLARP kinase, receptor interacting protein-2, and CARD-containing ICE associated kinase, respectively, (1-3). RICK contains an N-terminal kinase catalytic domain and a C-terminal CARD domain. Overexpression of RICK induced apoptosis and activation of NF-kappaB and JNK. RICK interacts with members of the TRAF family, CLARP and caspase-1. Thus, RICK represents a novel kinase that regulates TNF and Fas induced-apoptosis and that is involved in the generation of proinflammatory cytokine IL-1b. The messenger RNA of RICK is expressed in multiple human tissues.Synonyms: CARD-containing IL-1 beta ICE-kinase, CARDIAK, RICK, RIP-2, RIP-like-interacting CLARP kinase, RIP2, Receptor-interacting protein 2, Receptor-interacting serine/threonine-protein kinase 2

ID gène: 8767

UniProt: O43353

Pathways: TCR Signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Toll-Like Receptors Cascades