TARDBP anticorps (Center)

N° du produit ABIN500883

Cet anticorps anti-TARDBP est un anticorps Lapin Polyclonal détectant TARDBP dans WB, IF et EIA. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour TARDBP anticorps (Center) (ABIN500883)

Antigène: TARDBP (TAR DNA Binding Protein (TARDBP))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TARDBP est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Détail du produit anti-TARDBP anticorps

Épitope: Center

Specificité: At least two isoforms are known to exist for this protein, this TDP43 antibody only recongizes the longer of the two isoforms.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat

Purification: Peptide affinity chromatography

Immunogène: TDP43 antibody was raised against a 18 amino acid peptide from near the center of human TDP43.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 0.5 - 1 μg/mL. Immunoflourescence.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody (in aliquots) at -20 °C.

Détails sur TARDBP

Antigène: TARDBP (TAR DNA Binding Protein (TARDBP))

Autre désignation: TARDBP

Sujet: TDP43 was initially identified as a novel cellular protein that bound to HIV-1 virus TAR DNA sequence motifs and acts a transcriptional repressor to the HIV-1 LTR. Later experiments revealed that TDP43 also regulates the splicing of exon 9 of the cystic fibrosis transmembrane conductance regular (CFTR), most likely through the association with the UG repeats at the 3' splice site. A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43 known as pathologic TDP43 is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FLTD-U). TDP43 is not related to TRBP1, and RNA binding protein that binds HIV-1 TAR RNA sequences. At least two isoforms are known to exist for this protein, this TDP43 antibody only recongizes the longer of the two isoforms.Synonyms: TAR DNA-binding protein 43, TDP-43, TDP43

ID gène: 23435

NCBI Accession: NP_031401

Pathways: Positive Regulation of Peptide Hormone Secretion