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TNFAIP3 anticorps (Center)

TNFAIP3 Reactivité: Humain, Souris, Rat WB, IHC (p), EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN500996
  • Antigène Voir toutes TNFAIP3 Anticorps
    TNFAIP3 (Tumor Necrosis Factor, alpha-Induced Protein 3 (TNFAIP3))
    Épitope
    • 15
    • 5
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Center
    Reactivité
    • 53
    • 25
    • 25
    • 4
    • 1
    Humain, Souris, Rat
    Hôte
    • 47
    • 5
    • 1
    Lapin
    Clonalité
    • 37
    • 16
    Polyclonal
    Conjugué
    • 26
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp TNFAIP3 est non-conjugé
    Application
    • 24
    • 15
    • 14
    • 13
    • 9
    • 8
    • 8
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificité
    This antibody detects TNFAIP3 at Center.
    Réactivité croisée (Details)
    Species reactivity (tested):Human, mouse, rat
    Purification
    Peptide affinity chromatography
    Immunogène
    TNFAIP3 antibody was raised against a 17 amino acid peptide near the center of human TNFAIP3.
    Isotype
    IgG
    Top Product
    Discover our top product TNFAIP3 Anticorps primaire
  • Indications d'application
    ELISA. Western blot: 1 - 2 μg/mL. Immunohistochmistry on paraffin sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Antigène
    TNFAIP3 (Tumor Necrosis Factor, alpha-Induced Protein 3 (TNFAIP3))
    Autre désignation
    TNFAIP3 (TNFAIP3 Produits)
    Synonymes
    anticorps tnfaip3, anticorps MGC82339, anticorps TNFAIP3, anticorps A20, anticorps OTUD7C, anticorps TNFA1P2, anticorps Tnfip3, anticorps TNF alpha induced protein 3, anticorps TNF alpha induced protein 3 S homeolog, anticorps tumor necrosis factor, alpha-induced protein 3, anticorps TNFAIP3, anticorps tnfaip3.S, anticorps Tnfaip3
    Sujet
    TNFAIP3, also known as A20, is located in chromosome band 6q23, a region that is often deleted in B cell lymphomas. Recently, it was identified as a tumor suppressor gene in Hodgkin lymphoma and several subtypes of non-Hodgkin lymphomas. TNFAIP3 was initially identified as a zinc-finger protein that is rapidly and transiently induced by TNF-a, inhibiting NF-kB-dependent gene expression, and protecting cells from TNF-a-cytotoxicity. Overexpression of TNFAIP3 also inhibits the TLR2- and TLR4-mediated interleukin-8 synthesis in airway epithelial cells, suggesting that TNFAIP3 also acts as a negative regulator of TLR-mediated inflammatory responses, thereby protecting the host against harmful over-responses to pathogens. At least two isoforms of TNFAIP3 are known to exist.Synonyms: OTU domain-containing protein 7C, OTUD7C, Putative DNA-binding protein A20, Tumor necrosis factor alpha-induced protein 3, Zinc finger protein A20
    ID gène
    7128
    NCBI Accession
    NP_006281
    Pathways
    Signalisation TLR, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Production of Molecular Mediator of Immune Response
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