TRIM5 anticorps (Isoform alpha, Middle Region)

N° du produit ABIN501052

Détail du produit anti-TRIM5 anticorps

Antigène: TRIM5 (Tripartite Motif Containing 5 (TRIM5))

Épitope: Isoform alpha, Middle Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TRIM5 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: This antibody detects TRIM5 / RNF88 alpha at Center.

Réactivité croisée (Details): Species reactivity (tested):Human

Purification: Peptide affinity chromatography

Immunogène: TRIM5 alpha antibody was raised against a synthetic peptide corresponding to amino acids near the mid-region of human TRIM5 alpha.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 1 to 2 μg/mL. A band at approximately 55 kDa can be detected. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur TRIM5

Antigène: TRIM5 (Tripartite Motif Containing 5 (TRIM5))

Autre désignation: TRIM5 / RNF88 (TRIM5 Produits)

Synonymes: anticorps TRIM5, anticorps RNF88, anticorps TRIM5alpha, anticorps EG667823, anticorps Gm8833, anticorps RGD1304579, anticorps tripartite motif containing 5, anticorps tripartite motif-containing 5, anticorps TRIM5, anticorps Trim5

Sujet: TRIM5 is a member of a broad family of otherwise unrelated proteins defined by the presence of a tripartite motif containing a RING domain, a B-box type 1, and a B-box type 2, followed by a coiled-coil region . TRIM5 has six alternately spliced isoforms, the longest of which is the alpha variant which also contains a carboxy-terminal B30.2 (SPRY) domain. Expression of TRIM5alpha variants from humans, rhesus monkeys, and African green monkeys enabled resistance to infection by various retroviruses including HIV-1, albeit at differing efficiencies. All TRIM5alpha variants could inhibit at least two different retroviruses, but not from those viruses isolated from the same species, suggesting that TRIM5alpha acts as a natural barrier to cross-species retrovirus transmission.Synonyms: RING finger protein 88, Tripartite motif-containing protein 5

ID gène: 85363

NCBI Accession: NP_149023

Pathways: Activation of Innate immune Response