TARDBP anticorps (AA 21-120) (AbBy Fluor® 750)

N° du produit ABIN5011352

Cet anticorps anti-TARDBP est un anticorps Lapin Polyclonal détectant TARDBP dans WB, IF (cc) et IF (p). Adapté pour Rat.

Aperçu rapide pour TARDBP anticorps (AA 21-120) (AbBy Fluor® 750) (ABIN5011352)

Antigène: TARDBP (TAR DNA Binding Protein (TARDBP))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TARDBP est conjugé à/à la AbBy Fluor® 750

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-TARDBP anticorps (AbBy Fluor® 750)

Épitope: AA 21-120

Réactivité croisée: Rat

Homologie: Human,Mouse,Cow,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human TDP-43

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur TARDBP

Antigène: TARDBP (TAR DNA Binding Protein (TARDBP))

Autre désignation: TARDBP

Sujet:

Synonyms: ALS10, TDP-43, TAR DNA-binding protein 43, TARDBP, TDP43

Background: DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR.

ID gène: 23435

UniProt: Q13148

Pathways: Positive Regulation of Peptide Hormone Secretion