CDC25A anticorps (AA 190-484)

N° du produit ABIN5027104

L’anticorps anti-CDC25A Monoclonal Souris est utilisé pour la détection de CDC25A dans des échantillons de Humain. Il a été validé pour WB et IHC.

Aperçu rapide pour CDC25A anticorps (AA 190-484) (ABIN5027104)

Antigène: CDC25A (Cell Division Cycle 25 Homolog A (S. Pombe) (CDC25A))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CDC25A est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: ABM4A46

Détail du produit anti-CDC25A anticorps

Épitope: AA 190-484

Purification: Protein G Chromatography

Immunogène: A partial length recombinant CDC25A protein (amino acids 190-484) was used as the immunogen for this antibody.

Isotype: IgG2b kappa

Information d'application

Indications d'application: WB: 2-4 μg/mL, IHC: 5 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Détails sur CDC25A

Antigène: CDC25A (Cell Division Cycle 25 Homolog A (S. Pombe) (CDC25A))

Autre désignation: CDC25A

Sujet: CDC25A is a dual specificity (tyr/thr) phosphatase and a putative upregulated c-Myc target gene. It is a regulator of the cell cycle required for progression from G1 to S phase. CDC25A is a member of the CDC25 family of phosphatases. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. Overexpression of CDC25A bypassed the mechanism of cell cycle arrest, leading to enhanced DNA damage and decreased cell survival. Specific degradation of CDC25A is identified as part of the DNA damage checkpoint mechanism and suggested how CDC25A overexpression in human cancers might contribute to tumorigenesis.

Poids moléculaire: 59 kDa

ID gène: 993

UniProt: P30304

Pathways: Cycle Cellulaire, Mitotic G1-G1/S Phases, M Phase