MITF anticorps (AA 150-427)

N° du produit ABIN5027358

Cet anticorps Souris Monoclonal détecte spécifiquement MITF dans WB et IHC. Il présente une réactivité envers Humain.

Aperçu rapide pour MITF anticorps (AA 150-427) (ABIN5027358)

Antigène: MITF (Microphthalmia-Associated Transcription Factor (MITF))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MITF est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: ABM1H91

Détail du produit anti-MITF anticorps

Épitope: AA 150-427

Réactivité croisée: Souris

Purification: Protein G Chromatography

Immunogène: A partial length recombinant MITF protein (amino acids 150-427) was used as the immunogen for this antibody.

Isotype: IgG1 kappa

Information d'application

Indications d'application: WB: 2-4 μg/mL, IHC: 10 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Détails sur MITF

Antigène: MITF (Microphthalmia-Associated Transcription Factor (MITF))

Autre désignation: MITF

Sujet: MITF (Microphthalmia-associated transcription factor) is a basic helix-loop-helix leucine zipper (bHLH-Zip) family factor, involved in lineage-specific pathway regulation of many types of cells including osteoclasts, melanocytes, retinal pigment epithelial cells, mast cells and natural killer cells. It plays a critical role in melanogenesis as a transcriptional activator of tyrosinase, TRP-1, and TRP-2. Moreover, it regulates specification, survival, and proliferation of normal melanocytes, and controls proliferation, migration and invasion of melanoma cells. MITF is the most characterized member of the MIT family, mutations of which can lead to diseases such as Melanoma, Waardenburg syndrome, and Tietz syndrome.

Poids moléculaire: 30 kDa

ID gène: 4286

UniProt: O75030

Pathways: Chromatin Binding