NLRP3 anticorps (AA 150-385)

N° du produit ABIN5027384

Cet anticorps anti-NLRP3 Monoclonal Souris (Clone ABM2D48) (ABIN5027384) détecte spécifiquement NLRP3 dans WB et IHC. L’anticorps est réactif avec des échantillons de Humain et Souris.

Aperçu rapide pour NLRP3 anticorps (AA 150-385) (ABIN5027384)

Antigène: NLRP3 (NLR Family, Pyrin Domain Containing 3 (NLRP3))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp NLRP3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: ABM2D48

Détail du produit anti-NLRP3 anticorps

Épitope: AA 150-385

Purification: Protein G Chromatography

Immunogène: A partial length recombinant NALP3 protein (amino acids 150-385) was used as the immunogen for this antibody.

Isotype: IgG2b kappa

Information d'application

Indications d'application: WB: 6-8 μg/mL, IHC: 5 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Détails sur NLRP3

Antigène: NLRP3 (NLR Family, Pyrin Domain Containing 3 (NLRP3))

Autre désignation: NALP3

Sujet: NALP3 (NACHT, LRR and PYD domains-containing protein 3), otherwise known as cryopyrin, is a member of the NLR (Nod-like-receptors) family. This is a pyrin-like protein, having N-terminal CARD or pyrin domains needed for homotypic protein protein interaction, an intermediate nucleotide binding self oligomerization NACHT domain and a C-terminal domain containing leucine rich repeats (LRRs). NALP3 is a key component of innate immunity and its expression is restricted to immune cells and chondrocytes. It interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kB signaling, and it plays an important role in the regulation of inflammation, the immune response, and apoptosis.

Poids moléculaire: 120 kDa

ID gène: 114548

UniProt: Q96P20

Pathways: Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Inflammasome