IL3RA anticorps (AA 120-323)

N° du produit ABIN5027448

Cet anticorps Souris Monoclonal détecte spécifiquement IL3RA dans FACS et WB. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour IL3RA anticorps (AA 120-323) (ABIN5027448)

Antigène: IL3RA (Interleukin 3 Receptor, alpha (IL3RA))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IL3RA est non-conjugé

Application: Flow Cytometry (FACS), Western Blotting (WB)

Clone: ABM25C1

Détail du produit anti-IL3RA anticorps

Épitope: AA 120-323

Purification: Protein G Chromatography

Immunogène: A partial length recombinant protein (a.a 120-323) of IL-3RA was used as the immunogen for this antibody.

Isotype: IgG2b kappa

Information d'application

Indications d'application: WB: 6-8 μg/mL, FACS: 0.5-1 μg/10^6

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Détails sur IL3RA

Antigène: IL3RA (Interleukin 3 Receptor, alpha (IL3RA))

Autre désignation: IL-3RA

Sujet: Interleukin-3 receptor subunit alpha (IL-3RA) or CD123 is a high-affinity receptor for interleukin-3 (IL-3), which along with the primary signaling common Beta (Beta c) subunit (CD131) forms a heterodimer, enabling cell signaling. IL-3RA chain is a glycoprotein of 360 amino acidic residues, composed by an extracellular domain of 287 amino acid residues, involving a predicted Ig-like domain, two Fn III domains, a transmembrane domain of 30 amino acid residues and by an intracellular domain of 53 residues. It is expressed on the majority of CD34+ hemopoietic progenitors and its expression is rapidly lost during erythroid and megakaryocytic differentiation, moderately decreased during monocytic differentiation and is sustained in the granulocytic lineage. IL-3RA is also expressed in a variety of hematological neoplasms including blastic plasmacytoid dendritic cell neoplasm (BPDCN), acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), chronic myeloid leukemia (CML), Hodgkin&rsquo,s lymphoma and hairy cell leukemia.

Poids moléculaire: 44 kDa

ID gène: 3563

UniProt: P26951

Pathways: Signalistation JAK/STAT