MYD88 anticorps (AA 13-221)

N° du produit ABIN5027489

Cet anticorps anti-MYD88 Monoclonal Souris (Clone ABM2H20) (ABIN5027489) détecte spécifiquement MYD88 dans WB et FACS. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour MYD88 anticorps (AA 13-221) (ABIN5027489)

Antigène: MYD88 (Myeloid Differentiation Primary Response Gene (88) (MYD88))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MYD88 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS)

Clone: ABM2H20

Détail du produit anti-MYD88 anticorps

Épitope: AA 13-221

Purification: Protein G Chromatography

Immunogène: A partial length recombinant protein of human MyD88 (amino acids 13-221) was used as an immunogen for this antibody.

Isotype: IgG1 kappa

Information d'application

Indications d'application: WB: 0.1-0.5 μg/mL,FACS: 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Détails sur MYD88

Antigène: MYD88 (Myeloid Differentiation Primary Response Gene (88) (MYD88))

Autre désignation: MyD88

Sujet: MyD88 (Myeloid differentiation factor) is an essential adaptor molecule in all TLR (Toll-like receptor) signaling pathways except TLR3. MyD88 is composed of an N-terminal (Death Domain) and a highly conserved C-terminal TIR (Toll/interleukin-1 Receptor) domain. It is found to stimulate IL-1R/IL18R-mediated signaling. MyD88-dependent signaling is also important in the regulation of innate as well as acquired immunity, in particular, T-cell responses, to various microbial pathogens. After activation of TLRs, MyD88 is phosphorylated and subsequently recruits IRAKs (IL-1R Associated Kinases) and other downstream proteins such as TRAF6, finally resulting in activation of the NF-kappaB (nuclear factor kappa B) pathway.

Poids moléculaire: 33 kDa

ID gène: 4615

UniProt: Q99836

Pathways: Signalisation NF-kappaB, Signalisation TLR, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades