PD-L1 anticorps (AA 13-224)
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- Antigène Voir toutes PD-L1 Anticorps
- PD-L1 (CD274 (PD-L1))
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Épitope
- AA 13-224
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp PD-L1 est non-conjugé
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Application
- Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (IHC)
- Purification
- Protein G Chromatography
- Immunogène
- A partial length recombinant protein of PD-L1 (amino acid 13-224) was used as the immunogen for this antibody.
- Clone
- ABM5F25
- Isotype
- IgG2b kappa
- Top Product
- Discover our top product PD-L1 Anticorps primaire
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- Indications d'application
- FACS: 0.5-1 μg/10^6 cells, WB: 2-4 μg/mL, IHC: 5-10 μg/mL
- Restrictions
- For Research Use only
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- Concentration
- 0.5 mg/mL
- Buffer
- PBS containing 0.05 % BSA, PH 7.4
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
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Prognostic significance of BIRC7/Livin, Bcl-2, p53, Annexin V, PD-L1, DARC, MSH2 and PMS2 in colorectal cancer treated with FOLFOX chemotherapy with or without aspirin." dans: PLoS ONE, Vol. 16, Issue 1, pp. e0245581, (2021) (PubMed).
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Prognostic significance of BIRC7/Livin, Bcl-2, p53, Annexin V, PD-L1, DARC, MSH2 and PMS2 in colorectal cancer treated with FOLFOX chemotherapy with or without aspirin." dans: PLoS ONE, Vol. 16, Issue 1, pp. e0245581, (2021) (PubMed).
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- Antigène
- PD-L1 (CD274 (PD-L1))
- Autre désignation
- PDL-1 (PD-L1 Produits)
- Synonymes
- anticorps B7-H, anticorps B7H1, anticorps PD-L1, anticorps PDCD1L1, anticorps PDCD1LG1, anticorps PDL1, anticorps A530045L16Rik, anticorps B7h1, anticorps Pdcd1l1, anticorps Pdcd1lg1, anticorps Pdl1, anticorps RGD1566211, anticorps CD274 molecule, anticorps CD274 antigen, anticorps programmed cell death 1 ligand 2, anticorps CD274, anticorps Cd274, anticorps PDCD1LG2
- Sujet
- PD-L1 (CD274/B7-H1) is a critical membrane-bound costimulatory molecule belongs to the B7 superfamily that inhibits immune responses through its receptor, PD-1 and PD-L1 play a key role in the pathogenesis of inflammatory diseases (programmed death 1). It is widely expressed in the mononuclear phagocyte system (MPS), may co-stimulate T cells and regulates inflammatory responses. PD-L1 exerts inflammation regulatory functions via a negative co-stimulatory effect on T cell functions to inhibit cytokine secretion, facilitate apoptosis of activated T cells and induce T cell anergy. Aberrant expression and dysregulation of CD274 have been reported during bacterial infection, inflammation and in numerous autoimmune diseases.
- Poids moléculaire
- 44 kDa
- ID gène
- 29126
- UniProt
- Q9NZQ7
- Pathways
- Cancer Immune Checkpoints
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