TLR10 anticorps (AA 100-369)

N° du produit ABIN5027569

L’anticorps anti-TLR10 Monoclonal Souris est utilisé pour la détection de TLR10 dans des échantillons de Humain. Il a été validé pour WB.

Aperçu rapide pour TLR10 anticorps (AA 100-369) (ABIN5027569)

Antigène: TLR10 (Toll-Like Receptor 10 (TLR10))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TLR10 est non-conjugé

Application: Western Blotting (WB)

Clone: ABM3C85

Détail du produit anti-TLR10 anticorps

Épitope: AA 100-369

Purification: Protein G Chromatography

Immunogène: A partial length recombinant TLR10 protein (amino acids 100-369) was used as the immunogen for this antibody.

Isotype: IgG2a kappa

Information d'application

Indications d'application: WB: 2-4 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Détails sur TLR10

Antigène: TLR10 (Toll-Like Receptor 10 (TLR10))

Autre désignation: TLR10

Sujet: TLR10 (Toll-Like Receptor10) is an orphan member of the TLR family and is the only pattern-recognition receptor without known ligand specificity and biological function. This protein plays a role in innate immune responses following viral infection. Influenza virus infection increased TLR10 expression and TLR10 contributed to innate immune sensing of viral infection leading to cytokine induction, including proinflammatory cytokines and interferons. Blocking TLR10 by antagonistic antibodies enhanced proinflammatory cytokine production, including IL-1Beta, specifically after exposure to TLR2 ligands. TLR10 is in a locus that also contains TLR1 and TLR6, two receptors known to function as coreceptors for TLR2. TLR10 is predominantly expressed in tissues rich in immune cells, such as spleen, lymph node, thymus, tonsil, and lung. Expression of TLR10 can be induced in B cells, dendritic cells, eosinophils, and neutrophils, as well as on nonimmune cells, such as trophoblasts.

Poids moléculaire: 116 kDa

ID gène: 81793

UniProt: Q9BXR5

Pathways: Signalisation TLR, Activation of Innate immune Response, Toll-Like Receptors Cascades