LDLR anticorps (AA 500-550)

N° du produit ABIN504726

Cet anticorps anti-LDLR est un anticorps Lapin Polyclonal détectant LDLR dans WB et IHC. Adapté pour Humain et Souris.

Aperçu rapide pour LDLR anticorps (AA 500-550) (ABIN504726)

Antigène: LDLR (Low Density Lipoprotein Receptor (LDLR))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LDLR est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-LDLR anticorps

Épitope: AA 500-550

Réactivité croisée: Humain, Souris, Primate

Purification: affinity purified

Immunogène: Synthetic peptide made to an internal portion of the human protein (within AA 500-550). [Swiss-Prot# P01130]

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Stock: -20 °C

Détails sur LDLR

Antigène: LDLR (Low Density Lipoprotein Receptor (LDLR))

Autre désignation: LDL Receptor

Sujet: The low density lipoprotein (LDL) receptor system coordinates the metabolism of cholesterol, an essential component of the plasma membrane of all mammalian cells. Study of this system has led to an enhanced understanding of the cellular basis of cholesterol homeostasis. It has also brought into focus an important mechanism of metabolic regulation--the process of receptor-mediated endocytosis (1). Data suggest that the juxtamembranous region of the cytoplasmic domain participates in protein:protein interactions that allow the low density lipoprotein receptor to cluster in coated pits (2). It has been shown that the family of LDL receptors may serve as viral receptors. Endocytosis of the Flaviviridae viruses, hepatitis C virus, GB virus C/hepatitis G virus, and bovine viral diarrheal virus (BVDV) was shown to be mediated by LDL receptors on cultured cells

UniProt: P01130

Pathways: Hepatitis C, Lipid Metabolism