Nibrin anticorps (AA 350-400)
Aperçu rapide pour Nibrin anticorps (AA 350-400) (ABIN504727)
Antigène
Voir toutes Nibrin (NBN) AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
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Épitope
- AA 350-400
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Réactivité croisée
- Humain, Souris
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Purification
- affinity purified
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Immunogène
- Synthetic peptide made to an internal portion of the mouse protein (within AA 350-400). [Swiss-Prot# Q9R207].
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Isotype
- IgG
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Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Stock
- -20 °C
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- Nibrin (NBN)
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Autre désignation
- p95/NBS1
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Sujet
- The p95 gene (identical to NBS1 and nibrin) is a member of the hMre11/hRad50 double-strand break complex. This protein complex has been implicated in Nijmegen breakage syndrome, an autosomal recessive disorder marked by increased cancer incidence, cell cycle checkpoint deficits, and ionizing radiation sensitivity, thus revealing a direct molecular link between double-strand break repair and cell cycle checkpoint functions.
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UniProt
- Q9R207
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Pathways
- Réparation de l'ADN, Production of Molecular Mediator of Immune Response
Antigène
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