Complement Factor B anticorps (N-Term)

N° du produit ABIN5514558

Cet anticorps Lapin Polyclonal détecte spécifiquement Complement Factor B dans WB. Il présente une réactivité avec des échantillons de Humain, Rat, Souris, Boeuf (Vache), Chien, Cobaye, Cheval, Lapin et Mouton.

Aperçu rapide pour Complement Factor B anticorps (N-Term) (ABIN5514558)

Antigène: Complement Factor B (CFB)

Reactivité: Humain, Rat, Souris, Boeuf (Vache), Chien, Cobaye, Cheval, Lapin, Mouton

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Complement Factor B est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Complement Factor B anticorps

Épitope: N-Term

Fonction: CFB Antibody - N-terminal region

Séquence: NGAGYCSNPG IPIGTRKVGS QYRLEDSVTY HCSRGLTLRG SQRRTCQEGG

Homologie: Cow: 93%, Dog: 86%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 86%, Rat: 100%, Sheep: 93%

Attributs du produit: This is a rabbit polyclonal antibody against CFAB. It was validated on Western Blot.

Purification: Affinity purified

Immunogène: The immunogen is a synthetic peptide directed towards the N-terminal region of Human CFAB

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP56331-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur Complement Factor B

Antigène: Complement Factor B (CFB)

Autre désignation: CFB

Sujet:

Background Information: This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2.

Gene Name: complement factor B

Alternative Symbols: BF, FB, BFD, GBG, CFAB, CFBD, PBF2, AHUS4, FBI12, H2-Bf, ARMD14

Protein Name: complement factor B

Poids moléculaire: 84kDa

ID gène: 629

NCBI Accession: NP_001701

UniProt: P00751

Pathways: Système du Complément, Proton Transport, Ribonucleoside Biosynthetic Process