Growth Hormone Receptor anticorps (N-Term)

N° du produit ABIN5514835

L’anticorps anti-Growth Hormone Receptor Polyclonal Lapin est utilisé pour la détection de Growth Hormone Receptor dans des échantillons de Humain et Cheval. Il a été validé pour WB.

Aperçu rapide pour Growth Hormone Receptor anticorps (N-Term) (ABIN5514835)

Antigène: Growth Hormone Receptor (GHR)

Reactivité: Humain, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Growth Hormone Receptor est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Growth Hormone Receptor anticorps

Épitope: N-Term

Fonction: GHR Antibody - N-terminal region

Séquence: LLTLALAGSS DAFSGSEATA AILSRAPWSL QSVNPGLKTN SSKEPKFTKC

Homologie: Horse: 83%, Human: 100%

Attributs du produit: This is a rabbit polyclonal antibody against GHR. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N-terminal region of Human GHR

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP44229-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur Growth Hormone Receptor

Antigène: Growth Hormone Receptor (GHR)

Autre désignation: GHR

Sujet:

Background Information: This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.

Gene Name: growth hormone receptor

Alternative Symbols: GHBP, GHIP

Protein Name: Growth hormone receptor

Poids moléculaire: 32kDa

ID gène: 2690

UniProt: P10912

Pathways: Signalisation NF-kappaB, Signalistation JAK/STAT, Response to Growth Hormone Stimulus