Lamin A/C anticorps (C-Term)

N° du produit ABIN5514925

L’anticorps Lapin Polyclonal anti-Lamin A/C a été validé pour WB. Il convient pour détecter Lamin A/C dans des échantillons de Humain.

Aperçu rapide pour Lamin A/C anticorps (C-Term) (ABIN5514925)

Antigène: Lamin A/C (LMNA)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Lamin A/C est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Lamin A/C anticorps

Épitope: C-Term

Séquence: RTSGRVAVEE VDEEGKFVRL RNKSNEDQSM GNWQIKRQNG DDPLLTYRFP

Attributs du produit: This is a rabbit polyclonal antibody against LMNA. It was validated on Western Blot.

Purification: Affinity purified

Immunogène: The immunogen is a synthetic peptide directed towards the C-terminal region of Human LMNA

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur Lamin A/C

Antigène: Lamin A/C (LMNA)

Autre désignation: LMNA

Sujet: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.

Alias Symbols: LMNA, LMN1,

Protein Interaction Partner: LMNA, RAPGEF2, FUS, KRTAP10-3, KRTAP10-7, DUSP13, UBC, TP53, SUMO2, SUMO3, MDM2, EED, KIAA0196, ROCK2, ZW10, NCL, EEF1D, PSMD10, GMPPB, KPNA6, KCTD12, PARK2, FBXO6, YWHAQ, ZNF280C, PGRMC2, SCML2, HNRNPR, TRIM28, ZBTB33, NUP153, THRAP3, USP15, POM121, DDX4

Protein Size: 664

ID gène: 4000

UniProt: P02545

Pathways: Apoptose, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus