ABI1 anticorps (N-Term)

N° du produit ABIN5515797

Cet anticorps Lapin Polyclonal détecte spécifiquement ABI1 dans WB. Il présente une réactivité envers Humain, Rat, Souris, Cheval, Lapin, Boeuf (Vache), Cobaye, Chien, Poisson zèbre (Danio rerio) et Porc.

Aperçu rapide pour ABI1 anticorps (N-Term) (ABIN5515797)

Antigène: ABI1 (Abl-Interactor 1 (ABI1))

Reactivité: Humain, Rat, Souris, Cheval, Lapin, Boeuf (Vache), Cobaye, Chien, Poisson zèbre (Danio rerio), Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ABI1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-ABI1 anticorps

Épitope: N-Term

Séquence: MAELQMLLEE EIPSGKRALI ESYQNLTRVA DYCENNYIQA TDKRKALEET

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%

Attributs du produit: This is a rabbit polyclonal antibody against ABI1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N-terminal region of Human ABI1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur ABI1

Antigène: ABI1 (Abl-Interactor 1 (ABI1))

Autre désignation: ABI1

Sujet: This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t(10,11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14.

Alias Symbols: ABI-1, ABLBP4, E3B1, NAP1BP, SSH3BP, SSH3BP1

Protein Interaction Partner: ABL1, UBC, PRPF40A, TCERG1, GAS7, APBB1, SRRM1, PRKAA1, PIK3R1, CDC123, CTTN, NCK2, NCK1, CBL, CACNA1A, RYK, EPS8L1, ENAH, MINK1, EVL, NIN, CYFIP2, HSPA8, WASF2, WASF1, PAK2, NCKAP1, ABI1, VASP, SOS2, EPS8, NCF1, SPTA1, SPTAN1, SOS1, NEB, EPS8L3, EPS8L2,

Protein Size: 508

ID gène: 10006

NCBI Accession: NM_005470, NP_005461

UniProt: Q8IZP0

Pathways: Signalisation RTK, Response to Water Deprivation, ER-Nucleus Signaling