Cyclin D1 anticorps (CCND1) (AA 19-37)

Details for Product anti-CCND1 Antibody No. ABIN5518654
Antigène
  • BCL1
  • D11S287E
  • PRAD1
  • U21B31
  • AI327039
  • CycD1
  • Cyl-1
  • bcl-1
  • cD1
  • cb161
  • cycd1
  • etID37810.7
  • fb52e01
  • fc45c08
  • fc83a12
  • id:ibd1198
  • wu:fb52e01
  • wu:fc45c08
  • wu:fc83a12
  • ccnd1b
  • prad1
  • ccnd1
  • ccnd1a
  • bcl1
  • d11s287e
  • u21b31
  • CCND1
  • cyclin D1
  • cyclin D1 S homeolog
  • cyclin D1 L homeolog
  • CCND1
  • Ccnd1
  • ccnd1
  • ccnd1.S
  • ccnd1.L
Épitope
AA 19-37, N-Term
58
36
36
27
25
16
13
12
10
9
8
8
7
6
5
5
5
5
4
4
4
4
4
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Reactivité
Humain, Rat (Rattus)
516
258
232
45
19
16
16
11
4
4
4
4
3
3
2
2
2
2
2
1
1
1
1
1
Hôte
Lapin
399
179
5
Clonalité
Polyclonal
Conjugué
Cet anticorp Cyclin D1 est non-conjugé
34
25
15
9
7
7
6
6
6
6
6
6
4
4
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
Application
Western Blotting (WB)
490
169
169
113
101
82
77
47
40
25
23
9
8
7
2
1
1
1
Options
Fonction Rabbit IgG polyclonal antibody for G1/S-specific cyclin-D1(CCND1) detection. Tested with WB in Human,Rat.
Immunogène A synthetic peptide corresponding to a sequence at the N-terminus of human Cyclin D1(19-37aa DANLLNDRVLRAMLKAEET), different from the related mouse and rat sequences by two amino acids.
Séquence DANLLNDRVL RAMLKAEET
Isotype IgG
Réactivité croisée (Details) No cross reactivity with other proteins.
Attributs du produit Rabbit IgG polyclonal antibody for G1/S-specific cyclin-D1(CCND1) detection. Tested with WB in Human,Rat.
Gene Name: cyclin D1
Protein Name: G1/S-specific cyclin-D1
Purification Immunogen affinity purified.
Plasmids, Primers & others Plasmids, Primers & others Cyclin D1 products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation CCND1 (CCND1 Antibody Extrait)
Sujet Cyclin D1, also known as CCND1, is a human gene. The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclin D1 encodes the regulatory subunit of a holoenzyme that phosphorylates and inactivates the retinoblastoma protein and promotes progression through the G1-S phase of the cell cycle. Amplification or overexpression of cyclin D1 plays pivotal roles in the development of a subset of human cancers including parathyroid adenoma, breast cancer, colon cancer, lymphoma, melanoma, and prostate cancer. The cyclin D1 gene is overexpressed in human breast cancers and is required for oncogene-induced tumorigenesis. Brisken et al. (2003) found that prolactin (PRL, 176760) induced IGF2 (147470) mRNA and IGF2 induced cyclin D1 protein expression in mouse mammary epithelial cultures. And they also concluded that IGF2 is a mediator of prolactin-induced alveologenesis and that prolactin, IGF2, and cyclin D1 are components of a developmental pathway in mammary gland.

Synonyms: AI327039 antibody|B cell ccl/lymphoma 1 antibody|B cell CLL/lymphoma 1 antibody|B cell leukemia 1 antibody|B-cell leukemia 1 antibody|B cell lymphoma 1 protein antibody|B-cell lymphoma 1 protein antibody|BCL 1 antibody|BCL-1 antibody|BCL-1 oncogene antibody|BCL1 antibody|BCL1 oncogene antibody|CCND 1 antibody|CCND1 antibody|CCND1 protein antibody|CCND1/FSTL3 fusion gene, included antibody|CCND1/IGHG1 fusion gene antibody|CCND1/IGHG1 fusion gene, included antibody|CCND1/IGLC1 fusion gene, included antibody|CCND1/PTH fusion gene, included antibody|CCND1_HUMAN antibody|cD1 antibody|Cyl 1 antibody|D11S287E antibody|G1/S specific cyclin D1 antibody|G1/S-specific cyclin-D1 antibody|Parathyroid adenomatosis 1 antibody|PRAD1 antibody|PRAD1 oncogene antibody|U21B31 antibody
ID gène 595
UniProt P24385
Pathways Signalisation PI3K-Akt, Cycle Cellulaire, Mitotic G1-G1/S Phases, ER-Nucleus Signaling
Indications d'application WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat, The detection limit for CCND1 is approximately 2.5 ng/lane under reducing conditions.
Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users.
Commentaires

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
Concentration 500 μg/mL
Buffer Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
Agent conservateur Sodium azide, Thimerosal (Merthiolate)
Précaution d'utilisation This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
Stock 4 °C,-20 °C
Stockage commentaire At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
Images (Fournisseur)
Western Blotting (WB) image for anti-Cyclin D1 (CCND1) (AA 19-37), (N-Term) antibody (ABIN5518654) Anti- Cyclin D1 antibody, All Western blottingAll lanes: Anti-CCND1 at 0.5ug/ml Lane ...
Produit citée dans: Yang, Gao, Ma, Teng, Liu, Wei, Lu, Cheng, Hou, Zou: "Fucoidan inhibits lymphangiogenesis by downregulating the expression of VEGFR3 and PROX1 in human lymphatic endothelial cells." dans: Oncotarget, Vol. 7, Issue 25, pp. 38025-38035, 2018 (PubMed).

Feng, Yan, Zhou, Liang, Liang, Zhao, Dong, Ling: "Piwil2 is reactivated by HPV oncoproteins and initiates cell reprogramming via epigenetic regulation during cervical cancer tumorigenesis." dans: Oncotarget, Vol. 7, Issue 40, pp. 64575-64588, 2018 (PubMed).

Liao, Xiao, Chen, Zhang, Chen, Long, Gao, He, Ge, Yi, Wu, Li, Zhou: "The receptor for activated protein kinase C promotes cell growth, invasion and migration in cervical cancer." dans: International journal of oncology, Vol. 51, Issue 5, pp. 1497-1507, 2018 (PubMed).

Cheng, Wang, Wang, Wang, Du, Lou: "Silencing Ras-Related C3 Botulinum Toxin Substrate 1 Inhibits Growth and Migration of Hypopharyngeal Squamous Cell Carcinoma via the P38 Mitogen-Activated Protein Kinase Signaling Pathway." dans: Medical science monitor : international medical journal of experimental and clinical research, Vol. 24, pp. 768-781, 2018 (PubMed).

Li, Zheng, Ji, Liu, Lv, Yang, Hu, Chen, Zhang, Cao: "Effects of low-intensity ultrasound combined with low-dose carboplatin in an orthotopic hamster model of tongue cancer: A preclinical study." dans: Oncology reports, Vol. 39, Issue 4, pp. 1609-1618, 2018 (PubMed).

Liu, Lin, Mi, Li, Zhang: "Grape Seed Proanthocyanidin Extract Prevents Ovarian Aging by Inhibiting Oxidative Stress in the Hens." dans: Oxidative medicine and cellular longevity, Vol. 2018, pp. 9390810, 2018 (PubMed).

Li, Wang, Zhou, Shuang, Zhao, Chen: "Up-Regulation of Long Noncoding RNA SRA Promotes Cell Growth, Inhibits Cell Apoptosis, and Induces Secretion of Estradiol and Progesterone in Ovarian Granular Cells of Mice." dans: Medical science monitor : international medical journal of experimental and clinical research, Vol. 24, pp. 2384-2390, 2018 (PubMed).

Xiao, Dong, Cheng, Mao, Zong, Wu, Wang, Xie, Wang, Lei, Guo: "LRIG2 promotes the proliferation and cell cycle progression of glioblastoma cells in vitro and in vivo through enhancing PDGFRβ signaling." dans: International journal of oncology, Vol. 53, Issue 3, pp. 1069-1082, 2018 (PubMed).

Ren, Qiu, Lü, Ru, Li, Xiang, Yu, Zhang: "TALENs-directed knockout of the full-length transcription factor Nrf1α that represses malignant behaviour of human hepatocellular carcinoma (HepG2) cells." dans: Scientific reports, Vol. 6, pp. 23775, 2017 (PubMed).

Zhang, Chang, Zhao, Gao, Wang, Li, Zhang, Zhang, Xu: "The novel protein C9orf116 promotes rat liver cell line BRL-3A proliferation." dans: PLoS ONE, Vol. 12, Issue 7, pp. e0180607, 2017 (PubMed).

Ji, Liu, Zhao, Guo, Xia, Lu, Yin, Xu: "Triptolide inhibits proliferation, differentiation and induces apoptosis of osteoblastic MC3T3‑E1 cells." dans: Molecular medicine reports, Vol. 16, Issue 5, pp. 7391-7397, 2017 (PubMed).

Yuan, Zheng, Li, Xiang, Gao, Ran, Sun, Huang, Xie, Du, Xiao: "Overexpression of miR-30a in lung adenocarcinoma A549 cell line inhibits migration and invasion via targeting EYA2." dans: Acta biochimica et biophysica Sinica, Vol. 48, Issue 3, pp. 220-8, 2016 (PubMed).

Xu, Gu, Ni, Li, Yu, Li, Liu: "The expression of AEG-1 and Cyclin D1 in human bladder urothelial carcinoma and their clinicopathological significance." dans: International journal of clinical and experimental medicine, Vol. 8, Issue 11, pp. 21222-8, 2016 (PubMed).

Wang, Wang, Xiong, Chen, Ma, Cai, Gao, Sun, Yang, Pang: "Sirt1 AS lncRNA interacts with its mRNA to inhibit muscle formation by attenuating function of miR-34a." dans: Scientific reports, Vol. 6, pp. 21865, 2016 (PubMed).

Fan, Li, Li, Wang, Du, Yang, Zhao, Li: "Silencing of carboxypeptidase E inhibits cell proliferation, tumorigenicity, and metastasis of osteosarcoma cells." dans: OncoTargets and therapy, Vol. 9, pp. 2795-803, 2016 (PubMed).

Ren, Huang, Xu, Yang, Yang, Hu: "Isoflavone lupiwighteone induces cytotoxic, apoptotic, and antiangiogenic activities in DU-145 prostate cancer cells." dans: Anti-cancer drugs, Vol. 26, Issue 6, pp. 599-611, 2015 (PubMed).

He, Chen, Wang, Zhao, Wan, Wang, Mo: "miR-204-5p promotes the adipogenic differentiation of human adipose-derived mesenchymal stem cells by modulating DVL3 expression and suppressing Wnt/?-catenin signaling." dans: International journal of molecular medicine, Vol. 35, Issue 6, pp. 1587-95, 2015 (PubMed).

Li, Gao, Chu, Teng, Lv, Yang, Yin: "The synergistic antitumor effects of all-trans retinoic acid and C-phycocyanin on the lung cancer A549 cells in vitro and in vivo." dans: European journal of pharmacology, Vol. 749, pp. 107-14, 2015 (PubMed).

Gao, Tang, He, Liu, Mao, Ji, Lin, Wu: "Glycyrrhizic acid alleviates bleomycin-induced pulmonary fibrosis in rats." dans: Frontiers in pharmacology, Vol. 6, pp. 215, 2015 (PubMed).

Zhang, Hu, Liu, Ye, Gui, Zhou, Qi, He, Wang, Wang: "CD11b deficiency suppresses intestinal tumor growth by reducing myeloid cell recruitment." dans: Scientific reports, Vol. 5, pp. 15948, 2015 (PubMed).