HSD11B1 anticorps (N-Term)

N° du produit ABIN5518666

L’anticorps Lapin Polyclonal anti-HSD11B1 a été validé pour WB et IHC. Il convient pour détecter HSD11B1 dans des échantillons de Humain, Rat, Souris et Singe.

Aperçu rapide pour HSD11B1 anticorps (N-Term) (ABIN5518666)

Antigène: HSD11B1 (Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1))

Reactivité: Humain, Rat, Souris, Singe

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HSD11B1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-HSD11B1 anticorps

Épitope: AA 16-33, N-Term

Fonction: Anti-HSD11B1 Antibody Picoband®

Séquence: MAYYYYSANE EFRPEMLQ

Réactivité croisée (Details): No cross-reactivity with other proteins

Attributs du produit: Anti-HSD11B1 Antibody (ABIN5518666). Tested in IHC, WB applications. This antibody reacts with Human, Monkey, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the N-terminus of human HSD11B1, different from the related mouse sequence by two amino acids, and from the related rat sequence by four amino acids.

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.1-0.5 μg/mL, Human, Monkey, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human
1. "Entrez Gene: HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1".

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Détails sur HSD11B1

Antigène: HSD11B1 (Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1))

Autre désignation: HSD11B1

Sujet:

Synonyms: Corticosteroid 11-beta-dehydrogenase isozyme 1,1.1.1.146,11-beta-hydroxysteroid dehydrogenase 1,11-DH,11-beta-HSD1,Short chain dehydrogenase/reductase family 26C member 1,HSD11B1,HSD11, HSD11L, SDR26C1,

Tissue Specificity: Widely expressed. Highest expression in liver.

Background: 11beta-hydroxysteroid dehydrogenase type 1 is an NADPH-dependent enzyme highly expressed in key metabolic tissues including liver, adipose tissue, and the central nervous system. In these tissues, HSD11B1 reduces cortisone to the active hormone cortisol that activates glucocorticoid receptors. It is inhibited by carbenoxolone, a drug typically used in the treatment of peptic ulcers. Tannin et al. (1991) localized the HSD11B1 gene to chromosome 1. The localization was confirmed by isolating the gene from a chromosome 1-specific library using the cDNA as a probe. Schutte et al. (2000) mapped the HSD11B1 gene to 1q32-q41.

Sequence Similarities: Belongs to the connexin family. Beta-type (group I) subfamily.

Poids moléculaire: 36 kDa

UniProt: P28845

Pathways: Metabolism of Steroid Hormones and Vitamin D, Steroid Hormone Biosynthesis, Regulation of Carbohydrate Metabolic Process