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Caspase 1 anticorps (N-Term)

CASP1 Reactivité: Souris, Rat WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN5518669
  • Antigène Voir toutes Caspase 1 (CASP1) Anticorps
    Caspase 1 (CASP1)
    Épitope
    • 8
    • 7
    • 7
    • 6
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 137-157, N-Term
    Reactivité
    • 94
    • 35
    • 28
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Souris, Rat
    Hôte
    • 103
    • 11
    • 4
    • 1
    Lapin
    Clonalité
    • 94
    • 25
    Polyclonal
    Conjugué
    • 80
    • 18
    • 7
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp Caspase 1 est non-conjugé
    Application
    • 90
    • 47
    • 45
    • 24
    • 14
    • 14
    • 11
    • 6
    • 4
    • 3
    • 3
    • 1
    Western Blotting (WB)
    Fonction
    Rabbit IgG polyclonal antibody for Caspase-1(CASP1) detection. Tested with WB in Mouse,Rat.
    Séquence
    LEKAQKLWKE NPSEIYPIMN T
    Réactivité croisée (Details)
    No cross reactivity with other proteins.
    Attributs du produit
    Rabbit IgG polyclonal antibody for Caspase-1(CASP1) detection. Tested with WB in Mouse,Rat.
    Gene Name: caspase 1, apoptosis-related cysteine peptidase
    Protein Name: Caspase-1
    Purification
    Immunogen affinity purified.
    Immunogène
    A synthetic peptide corresponding to a sequence at the N-terminus of mouse CASP1(137-157aa LEKAQKLWKENPSEIYPIMNT), different from the related rat sequence by three amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product CASP1 Anticorps primaire
  • Indications d'application
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Mouse, Rat
    Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.
    Commentaires

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and IHC(F).

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Concentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    Agent conservateur
    Sodium azide, Thimerosal (Merthiolate)
    Précaution d'utilisation
    This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
  • Xu, Liu, Zhang, Wang, Wang, Yang, Huo, Sun: "Apoptosis-related protein expression in rabbits with blast brain injury following early hyperbaric oxygen therapy." dans: Neural regeneration research, Vol. 7, Issue 17, pp. 1318-24, (2015) (PubMed).

    Lu, Yuan, Ou, Cai, Wang, Sun, Zhang: "Autophagy and apoptosis during adult adipose-derived stromal cells differentiation into neuron-like cells in vitro." dans: Neural regeneration research, Vol. 7, Issue 16, pp. 1205-12, (2015) (PubMed).

    Chen, Peng, Rowat, Gao, Zhang, Wang, Zhang, Wang, Qu: "The effect of concentration and duration of normobaric oxygen in reducing caspase-3 and -9 expression in a rat-model of focal cerebral ischaemia." dans: Brain research, Vol. 1618, pp. 205-11, (2015) (PubMed).

    Ji, Yan, Li, Lai, Liu: "Therapeutic effects of intrathecal versus intravenous monosialoganglioside against bupivacaine-induced spinal neurotoxicity in rats." dans: Biomedicine & pharmacotherapy = Biome?decine & pharmacothe?rapie, Vol. 69, pp. 311-6, (2015) (PubMed).

    Wu, Wang, Hou: "Alpha B-crystallin improved survival of retinal ganglion cells in a rat model of acute ocular hypertension." dans: Neural regeneration research, Vol. 7, Issue 19, pp. 1493-7, (2015) (PubMed).

    Wang, Qu, Zhang, Zhang: "Testosterone suppresses ventricular remodeling and improves left ventricular function in rats following myocardial infarction." dans: Experimental and therapeutic medicine, Vol. 9, Issue 4, pp. 1283-1291, (2015) (PubMed).

    Liu, Chen, Wang, Yang, Xue, Zhu: "Msi1 confers resistance to TRAIL by activating ERK in liver cancer cells." dans: FEBS letters, Vol. 589, Issue 8, pp. 897-903, (2015) (PubMed).

    Peng, Liu, Wei, Lv, Wang, Xiong, Wang, Altaf, Wang, He, Wang, Qu: "P2X7R is involved in the progression of atherosclerosis by promoting NLRP3 inflammasome activation." dans: International journal of molecular medicine, Vol. 35, Issue 5, pp. 1179-88, (2015) (PubMed).

    Zhang, Yan, Hu, Zhuang, Yu, Hang: "Increased Expression of NLRP3 Inflammasome in Wall of Ruptured and Unruptured Human Cerebral Aneurysms: Preliminary Results." dans: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, Vol. 24, Issue 5, pp. 972-9, (2015) (PubMed).

    Huang, Huang, Xiao, Yang, Lin, Diao: "Kallistatin, a novel anti-angiogenesis agent, inhibits angiogenesis via inhibition of the NF-?B signaling pathway." dans: Biomedicine & pharmacotherapy = Biome?decine & pharmacothe?rapie, Vol. 68, Issue 4, pp. 455-61, (2014) (PubMed).

    Mao, Song, Li, Lv, Zhao, Li, Feng, Chen: "8-hydroxy-2-(di-n-propylamino)tetralin intervenes with neural cell apoptosis following diffuse axonal injury." dans: Neural regeneration research, Vol. 8, Issue 2, pp. 133-42, (2014) (PubMed).

    Dai, Li, Tang, Li, Xiao: "Colistin-induced nephrotoxicity in mice involves the mitochondrial, death receptor, and endoplasmic reticulum pathways." dans: Antimicrobial agents and chemotherapy, Vol. 58, Issue 7, pp. 4075-85, (2014) (PubMed).

    Yuan, Sun, Ou, Wang, Zhang, Deng, Wu, Zhang: "Apoptosis is an obstacle to the differentiation of adipose-derived stromal cells into astrocytes." dans: Neural regeneration research, Vol. 9, Issue 8, pp. 837-44, (2014) (PubMed).

    Chen, Dang, Wang, Tang, Liu, Wu: "The in vitro and in vivo anti-tumor effects of MTX-Fe3O 4-PLLA-PEG-PLLA microspheres prepared by suspension-enhanced dispersion by supercritical CO2." dans: Science China. Life sciences, Vol. 57, Issue 7, pp. 698-709, (2014) (PubMed).

    Shu, Yu, Zhang, Liu, Wu, Zang, Yang, Zhou, Yin: "Expression of TRPV1 in cortical lesions from patients with tuberous sclerosis complex and focal cortical dysplasia type IIb." dans: Brain & development, Vol. 35, Issue 3, pp. 252-60, (2013) (PubMed).

    Li, Peng, Song, Liang, Mei, Fang: "Electro-acupuncture combined with transcranial magnetic stimulation improves learning and memory function of rats with cerebral infarction by inhibiting neuron cell apoptosis." dans: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, Vol. 32, Issue 5, pp. 746-9, (2012) (PubMed).

    Li, Li, Huang, Kan, Wang, Wu, Yin, Yao: "Dexamethasone and A???-?? accelerate learning and memory impairments due to elevate amyloid precursor protein expression and neuronal apoptosis in 12-month male rats." dans: Behavioural brain research, Vol. 227, Issue 1, pp. 142-9, (2011) (PubMed).

    Fu, Zhao, Wu, Wu, Xu, Liu, Tong: "Therapeutic mechanisms of Tongmai Dasheng Tablet on tripterygium glycosides induced rat model for premature ovarian failure." dans: Journal of ethnopharmacology, Vol. 139, Issue 1, pp. 26-33, (2011) (PubMed).

    Zhao, Wu, Wu, Jia, Gao, Yan, Wang: "Introduction of hypoxia-targeting p53 fusion protein for the selective therapy of non-small cell lung cancer." dans: Cancer biology & therapy, Vol. 11, Issue 1, pp. 95-107, (2011) (PubMed).

    Ding, Zou, Li, Tian, Abdelalim, Du, She, Wang, Tan, Wang, Chen, Lv, Chang: "Study of histopathological and molecular changes of rat kidney under simulated weightlessness and resistance training protective effect." dans: PLoS ONE, Vol. 6, Issue 5, pp. e20008, (2011) (PubMed).

  • Antigène
    Caspase 1 (CASP1)
    Autre désignation
    CASP1 (CASP1 Produits)
    Synonymes
    anticorps ICE, anticorps IL1BC, anticorps P45, anticorps Il1bc, anticorps Ice, anticorps CASP1, anticorps CG5370, anticorps DCP-1, anticorps DCP1, anticorps Dcp1, anticorps Dmel\\CG5370, anticorps ccp1, anticorps dcp-1, anticorps dcp1, anticorps l(2)01862, anticorps l(2)02132, anticorps caspase 1, anticorps caspase 1, apoptosis-related cysteine peptidase, anticorps caspase 4, apoptosis-related cysteine peptidase, anticorps Death caspase-1, anticorps caspase-1, anticorps caspase, anticorps caspase recruitment domain-containing protein 16, anticorps caspase 4, anticorps CASP1, anticorps Casp1, anticorps CASP4, anticorps Dcp-1, anticorps Caspase1, anticorps LOC5564196, anticorps LOC451519
    Sujet
    Caspase 1 is a cysteine protease that regulates inflammatory processes through its capacity to process and activate the interleukin-1-beta, IL18, and IL33 precursor proteins. It belongs to a family of cysteine proteases known as caspases that always cleave proteins following an aspartic acid residue. The Caspase1 gene consists of 10 exons spanning at least 10.6 kb. The Caspase 1 gene is mapped to 11q23, a site frequently involved in rearrangement in human cancers, including a number of leukemias and lymphomas, by Southern DNA blot analysis of rodent-human hybrids and by in situ hybridization to normal human metaphase chromosomes. Caspase 1 has been shown to induce cell necrosis or pyroptosis and may function in various developmental stages.

    Synonyms: CASP 1 antibody|CASP-1 antibody|CASP1 antibody|Caspase 1 apoptosis related cysteine peptidase antibody|Caspase 1 apoptosis related cysteine protease antibody|Caspase-1 subunit p20 antibody|Caspase1 antibody|ICE antibody|IL 1 beta converting enzyme antibody|IL 1BC antibody|IL-1 beta-converting enzyme antibody|IL-1BC antibody|IL1 beta converting enzyme antibody|IL1B convertase antibody|IL1BC antibody|IL1BCE antibody|Interleukin 1 beta convertase antibody|Interleukin 1 beta convertase precursor antibody|Interleukin 1 beta converting enzyme antibody|Interleukin 1B converting enzyme antibody|Interleukin-1 beta convertase antibody|Interleukin-1 beta-converting enzyme antibody|P45 antibody
    UniProt
    P29452
    Pathways
    Apoptose, Interferon-gamma Pathway, Positive Regulation of Endopeptidase Activity, Inflammasome
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